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Literature summary extracted from

  • Ratner, S.
    Enzymes of arginine and urea synthesis (1973), Adv. Enzymol. Relat. Areas Mol. Biol., 39, 1-90.
    View publication on PubMed

Crystallization (Commentary)

EC Number Crystallization (Comment) Organism
6.3.4.5
-
Bos taurus

Inhibitors

EC Number Inhibitors Comment Organism Structure
6.3.4.5 AMP competitive with respect to ATP Bos taurus
6.3.4.5 D-Asp
-
Bos taurus
6.3.4.5 diphosphate
-
Bos taurus
6.3.4.5 erythro-3-Hydroxy-3-methylaspartate
-
Bos taurus
6.3.4.5 L-argininosuccinate competitive with respect to citrulline, Asp, and ATP Bos taurus
6.3.4.5 threo-3-Hydroxy-3-methylaspartate
-
Bos taurus

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
6.3.4.5 0.035
-
L-Asp
-
Bos taurus
6.3.4.5 0.88
-
threo-beta-methyl-L-Asp
-
Bos taurus
6.3.4.5 4.5
-
threo-beta-hydroxy-L-Asp
-
Bos taurus

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
3.5.3.1 30800
-
4 * 30800, sedimentation equilibrium urea Rattus norvegicus
6.3.4.5 45000
-
4 * 45000, two pairs of monomers crosslinked by disulfide bonds, SDS-PAGE in presence of reducing agent Bos taurus
6.3.4.5 90000
-
2 * 90000, SDS-PAGE in absence of reducing agent Bos taurus
6.3.4.5 175000
-
gel filtration Bos taurus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.5.3.1 L-arginine + H2O Rattus norvegicus
-
?
-
?

Organism

EC Number Organism UniProt Comment Textmining
3.5.3.1 Rattus norvegicus
-
-
-
6.3.4.5 Bos taurus
-
-
-

Reaction

EC Number Reaction Comment Organism Reaction ID
6.3.4.5 ATP + L-citrulline + L-aspartate = AMP + diphosphate + 2-(Nomega-L-arginino)succinate mechanism Bos taurus

Source Tissue

EC Number Source Tissue Comment Organism Textmining
6.3.4.5 kidney
-
Bos taurus
-
6.3.4.5 liver
-
Bos taurus
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
3.5.3.1 additional information
-
-
Rattus norvegicus
6.3.4.5 3.83
-
-
Bos taurus

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.5.3.1 L-arginine + H2O
-
Rattus norvegicus L-ornithine + urea
-
?
3.5.3.1 L-arginine + H2O
-
Rattus norvegicus ?
-
?
6.3.4.5 ATP + L-citrulline + L-Asp r Bos taurus AMP + diphosphate + L-argininosuccinate
-
?
6.3.4.5 ATP + L-citrulline + L-Asp D-Asp is inactive as substrate Bos taurus AMP + diphosphate + L-argininosuccinate
-
?
6.3.4.5 ATP + L-citrulline + threo-beta-hydroxy-DL-Asp
-
Bos taurus ?
-
?
6.3.4.5 ATP + L-citrulline + threo-beta-methyl-L-Asp
-
Bos taurus ?
-
?

Subunits

EC Number Subunits Comment Organism
3.5.3.1 tetramer 4 * 30800, sedimentation equilibrium urea Rattus norvegicus
6.3.4.5 tetramer 2 * 90000, SDS-PAGE in absence of reducing agent Bos taurus
6.3.4.5 tetramer 4 * 45000, two pairs of monomers crosslinked by disulfide bonds, SDS-PAGE in presence of reducing agent Bos taurus

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
6.3.4.5 6
-
reaction of AMP + diphosphate + L-argininosuccinate Bos taurus
6.3.4.5 8.7
-
reaction of ATP + L-citulline + L-Asp Bos taurus