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Literature summary extracted from

  • Kang, C.; Kim, S.; Fromm, H.J.
    Subunit complementation of Escherichia coli adenylosuccinate synthetase (1996), J. Biol. Chem., 271, 29722-29728.
    View publication on PubMed

Protein Variants

EC Number Protein Variants Comment Organism
6.3.4.4 R143L although the mutants R143L and D13A have low or no activity independently, when they are mixed, a significant amount of activity is obtained. These results indicate that the subunits exchange with each other to form heterodimers with a single viable active site Escherichia coli

General Stability

EC Number General Stability Organism
6.3.4.4 GTP and IMP stabilize the dimeric structure Escherichia coli

Organism

EC Number Organism UniProt Comment Textmining
6.3.4.4 Escherichia coli
-
wild-type and mutant enzymes R143L and D13A
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
6.3.4.4 GTP + IMP + L-Asp
-
Escherichia coli GDP + phosphate + adenylosuccinate
-
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