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Literature summary extracted from

  • Van der Weyden, M.B.; Kelly, W.N.
    Human adenylosuccinate synthetase. Partial purification, kinetic and regulatory properties of the enzyme from placenta (1974), J. Biol. Chem., 249, 7282-7289.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
6.3.4.4 3',5'-cyclic GMP
-
Homo sapiens
6.3.4.4 6-mercaptopurine ribonucleotide
-
Homo sapiens
6.3.4.4 adenosine 3',5'-AMP
-
Homo sapiens
6.3.4.4 adenylosuccinate competitive with respect to IMP Homo sapiens
6.3.4.4 ADP
-
Homo sapiens
6.3.4.4 AMP competitive with respect to IMP Homo sapiens
6.3.4.4 CDP
-
Homo sapiens
6.3.4.4 CMP
-
Homo sapiens
6.3.4.4 dAMP
-
Homo sapiens
6.3.4.4 dCMP
-
Homo sapiens
6.3.4.4 dGDP
-
Homo sapiens
6.3.4.4 dGMP
-
Homo sapiens
6.3.4.4 GDP competitive with respect to GTP Homo sapiens
6.3.4.4 GMP competitive with respect to GTP Homo sapiens
6.3.4.4 IDP
-
Homo sapiens
6.3.4.4 succinate
-
Homo sapiens
6.3.4.4 TDP
-
Homo sapiens
6.3.4.4 TMP
-
Homo sapiens
6.3.4.4 UDP
-
Homo sapiens
6.3.4.4 UMP
-
Homo sapiens
6.3.4.4 XMP competitive with respect to IMP Homo sapiens

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
6.3.4.4 0.031
-
GTP
-
Homo sapiens
6.3.4.4 0.037
-
IMP
-
Homo sapiens
6.3.4.4 0.95
-
Asp
-
Homo sapiens

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
6.3.4.4 Ba2+ can replace Mg2+ with lower efficiency Homo sapiens
6.3.4.4 Ca2+ can replace Mg2+ with lower efficiency Homo sapiens
6.3.4.4 Co2+ can replace Mg2+ with lower efficiency Homo sapiens
6.3.4.4 Mg2+ divalent cation required, maximal activity obtained with Mg2+ Homo sapiens
6.3.4.4 Mn2+ can replace Mg2+ with lower efficiency Homo sapiens
6.3.4.4 Ni2+ can replace Mg2+ with lower efficiency Homo sapiens

Organism

EC Number Organism UniProt Comment Textmining
6.3.4.4 Homo sapiens
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
6.3.4.4 partial Homo sapiens

Reaction

EC Number Reaction Comment Organism Reaction ID
6.3.4.4 GTP + IMP + L-aspartate = GDP + phosphate + N6-(1,2-dicarboxyethyl)-AMP sequential rapid equilibrium fully random mechanism Homo sapiens

Source Tissue

EC Number Source Tissue Comment Organism Textmining
6.3.4.4 placenta
-
Homo sapiens
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
6.3.4.4 0.00641
-
-
Homo sapiens

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
6.3.4.4 GTP + IMP + L-Asp
-
Homo sapiens GDP + phosphate + adenylosuccinate
-
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pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
6.3.4.4 6.5 7.4
-
Homo sapiens