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Literature summary extracted from

  • Spector, T.; Miller, R.L.
    Mammalian adenylosuccinate synthetase. Nucleotide monophosphate substrates and inhibitors (1976), Biochim. Biophys. Acta, 445, 509-517.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
6.3.4.4 3',5'-cyclic GMP
-
 Oryctolagus cuniculus
6.3.4.4 6-Thio-GMP
-
 Oryctolagus cuniculus
6.3.4.4 6-thio-IMP
-
 Oryctolagus cuniculus
6.3.4.4 8-Aza-7-deaza-GMP competitive with respect to GTP Oryctolagus cuniculus
6.3.4.4 8-aza-GMP competitive with respect to GTP Oryctolagus cuniculus
6.3.4.4 8-Aza-IMP
-
 Oryctolagus cuniculus
6.3.4.4 allopurinol nucleotide
-
 Oryctolagus cuniculus
6.3.4.4 arabinosyl-GMP beta-D-arabinosyl-GMP, competitive with respect to GTP Oryctolagus cuniculus
6.3.4.4 dGMP 2'-dGMP Oryctolagus cuniculus
6.3.4.4 GMP
-
 Oryctolagus cuniculus
6.3.4.4 XMP
-
 Oryctolagus cuniculus

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
6.3.4.4 0.26
-
 arabinosylIMP 2'-dIMP Oryctolagus cuniculus
6.3.4.4 0.33
-
 Asp IMP Oryctolagus cuniculus
6.3.4.4 0.85
-
 beta-D-arabinosylIMP
-
 Oryctolagus cuniculus

Organism

EC Number Organism UniProt Comment Textmining
6.3.4.4 Oryctolagus cuniculus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
6.3.4.4 muscle
-
 Oryctolagus cuniculus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
6.3.4.4 GTP + 2'-dIMP + L-Asp 61% of the efficiency of IMP as substrate, V/Km Oryctolagus cuniculus GDP + phosphate + 2'-deoxysuccinoAMP
-
 ?
6.3.4.4 GTP + beta-D-arabinosylIMP + L-Asp 8.8% of the efficiency of IMP as substrate , V/Km Oryctolagus cuniculus GDP + phosphate + arabinosylsuccinoAMP
-
 ?
6.3.4.4 GTP + IMP + 6-methoxypurine nucleotide
-
 Oryctolagus cuniculus ?
-
 ?
6.3.4.4 GTP + IMP + L-Asp
-
 Oryctolagus cuniculus GDP + phosphate + adenylosuccinate
-
 ?