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Literature summary extracted from

  • Porter, D.J.T.; Rudie, N.G.; Bright, H.J.
    Nitro analogs of substrates for adenylosuccinate synthetase and adenylosuccinate lyase (1983), Arch. Biochem. Biophys., 225, 157-163.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
4.3.2.2 N6-(L-1-carboxy-2-nitroethyl)-AMP competitive Saccharomyces cerevisiae
4.3.2.2 nitroacrylate 0.02 mM, 70% inactivation Saccharomyces cerevisiae
6.3.4.4 4-Oxo-2-aminopentanoic acid i.e. 2-oxonorvaline, poor Azotobacter vinelandii
6.3.4.4 cyanoalanine poor Azotobacter vinelandii
6.3.4.4 cysteine poor Azotobacter vinelandii
6.3.4.4 cysteine sulfonate poor Azotobacter vinelandii
6.3.4.4 homocysteine poor Azotobacter vinelandii
6.3.4.4 methionine sulfone poor Azotobacter vinelandii
6.3.4.4 N-Hydroxyaspartate poor Azotobacter vinelandii
6.3.4.4 N-methylaspartate poor Azotobacter vinelandii

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
4.3.2.2 N6-(1,2-dicarboxyethyl)AMP Saccharomyces cerevisiae enzyme catalyzes the last step in the pathway of AMP biosynthesis fumarate + AMP
-
 ?
6.3.4.4 GTP + IMP + L-Asp Azotobacter vinelandii penultimate step in pathway of AMP biosynthesis ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
4.3.2.2 Saccharomyces cerevisiae
-
-
-
6.3.4.4 Azotobacter vinelandii
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
4.3.2.2
-
 Saccharomyces cerevisiae

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
4.3.2.2 additional information
-
-
 Saccharomyces cerevisiae

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
4.3.2.2 N6-(1,2-dicarboxyethyl)AMP i.e. adenylosuccinate Saccharomyces cerevisiae fumarate + AMP
-
 ?
4.3.2.2 N6-(1,2-dicarboxyethyl)AMP enzyme catalyzes the last step in the pathway of AMP biosynthesis Saccharomyces cerevisiae fumarate + AMP
-
 ?
6.3.4.4 GTP + IMP + Ala-3-nitronate
-
 Azotobacter vinelandii GDP + phosphate + N6-(L-1-carboxy-2-nitroethyl)AMP
-
 ?
6.3.4.4 GTP + IMP + cysteine sulfinate
-
 Azotobacter vinelandii ?
-
 ?
6.3.4.4 GTP + IMP + L-Asp
-
 Azotobacter vinelandii GDP + phosphate + adenylosuccinate
-
 ?
6.3.4.4 GTP + IMP + L-Asp penultimate step in pathway of AMP biosynthesis Azotobacter vinelandii ?
-
 ?