EC Number | Inhibitors | Comment | Organism | Structure |
---|---|---|---|---|
2.1.1.140 | S-adenosyl-L-methionine | 50% inhibition at 0.062 mM, substrate (S)-coclaurine | Tinospora cordifolia |
EC Number | KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|---|
2.1.1.140 | 0.04 | - |
S-adenosyl-L-methionine | - |
Tinospora cordifolia | |
2.1.1.140 | 0.04 | - |
(S)-Coclaurine | - |
Tinospora cordifolia | |
2.1.1.140 | 0.05 | - |
(S)-norcoclaurine | probably allosteric enzyme, Hill coeffizient 2.6 | Tinospora cordifolia |
EC Number | Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|---|
2.1.1.140 | 83000 | - |
gel filtration HPLC | Tinospora cordifolia |
2.1.1.140 | 87000 | - |
gel filtration | Tinospora cordifolia |
EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
2.1.1.140 | (S)-coclaurine + S-adenosyl-L-methionine | Eschscholzia californica | - |
S-adenosyl-L-homocysteine + (S)-N-methylcoclaurine | - |
? | |
2.1.1.140 | (S)-coclaurine + S-adenosyl-L-methionine | Lamprocapnos spectabilis | - |
S-adenosyl-L-homocysteine + (S)-N-methylcoclaurine | - |
? | |
2.1.1.140 | (S)-coclaurine + S-adenosyl-L-methionine | Fumaria officinalis | - |
S-adenosyl-L-homocysteine + (S)-N-methylcoclaurine | - |
? | |
2.1.1.140 | (S)-coclaurine + S-adenosyl-L-methionine | Berberis koetineana | - |
S-adenosyl-L-homocysteine + (S)-N-methylcoclaurine | - |
? | |
2.1.1.140 | (S)-coclaurine + S-adenosyl-L-methionine | Berberis stolonifera | - |
S-adenosyl-L-homocysteine + (S)-N-methylcoclaurine | - |
? | |
2.1.1.140 | (S)-coclaurine + S-adenosyl-L-methionine | Bocconia cordata | - |
S-adenosyl-L-homocysteine + (S)-N-methylcoclaurine | - |
? | |
2.1.1.140 | (S)-coclaurine + S-adenosyl-L-methionine | Corydalis vaginans | - |
S-adenosyl-L-homocysteine + (S)-N-methylcoclaurine | - |
? | |
2.1.1.140 | (S)-coclaurine + S-adenosyl-L-methionine | Stephania delavayi | - |
S-adenosyl-L-homocysteine + (S)-N-methylcoclaurine | - |
? | |
2.1.1.140 | (S)-coclaurine + S-adenosyl-L-methionine | Tinospora cordifolia | - |
S-adenosyl-L-homocysteine + (S)-N-methylcoclaurine | - |
? | |
2.1.1.140 | (S)-coclaurine + S-adenosyl-L-methionine | Berberis canadensis | - |
S-adenosyl-L-homocysteine + (S)-N-methylcoclaurine | - |
? | |
2.1.1.140 | (S)-coclaurine + S-adenosyl-L-methionine | Cocculus trilobus | - |
S-adenosyl-L-homocysteine + (S)-N-methylcoclaurine | - |
? | |
2.1.1.140 | (S)-coclaurine + S-adenosyl-L-methionine | Tinospora fragosa | - |
S-adenosyl-L-homocysteine + (S)-N-methylcoclaurine | - |
? | |
2.1.1.140 | (S)-coclaurine + S-adenosyl-L-methionine | Thalictrum dasycarpum | - |
S-adenosyl-L-homocysteine + (S)-N-methylcoclaurine | - |
? | |
2.1.1.140 | (S)-coclaurine + S-adenosyl-L-methionine | Thalictrum flavum | - |
S-adenosyl-L-homocysteine + (S)-N-methylcoclaurine | - |
? | |
2.1.1.140 | (S)-coclaurine + S-adenosyl-L-methionine | Thalictrum glaucum | - |
S-adenosyl-L-homocysteine + (S)-N-methylcoclaurine | - |
? |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
2.1.1.140 | Berberis canadensis | - |
- |
- |
2.1.1.140 | Berberis koetineana | - |
- |
- |
2.1.1.140 | Berberis stolonifera | - |
- |
- |
2.1.1.140 | Bocconia cordata | - |
- |
- |
2.1.1.140 | Cocculus trilobus | - |
- |
- |
2.1.1.140 | Corydalis vaginans | - |
- |
- |
2.1.1.140 | Eschscholzia californica | - |
- |
- |
2.1.1.140 | Fumaria officinalis | - |
- |
- |
2.1.1.140 | Lamprocapnos spectabilis | - |
- |
- |
2.1.1.140 | Stephania delavayi | - |
- |
- |
2.1.1.140 | Thalictrum dasycarpum | - |
- |
- |
2.1.1.140 | Thalictrum flavum | - |
- |
- |
2.1.1.140 | Thalictrum glaucum | - |
- |
- |
2.1.1.140 | Tinospora cordifolia | - |
- |
- |
2.1.1.140 | Tinospora fragosa | - |
- |
- |
EC Number | Purification (Comment) | Organism |
---|---|---|
2.1.1.140 | 40% ammonium sulfate, Phenyl Sepharose, TSK Fraktogel, Mono Q, Affinity gel, disc electrophoresis, 115fold purification | Tinospora cordifolia |
EC Number | Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|---|
2.1.1.140 | 0.000096 | - |
enzyme extract of cell culture, (S)-coclaurine, (R)coclaurine is not methylated | Lamprocapnos spectabilis |
2.1.1.140 | 0.000096 | - |
enzyme extract of cell culture, (S)-coclaurine, (R)coclaurine is not methylated | Fumaria officinalis |
2.1.1.140 | 0.0001 | - |
enzyme extract of cell culture, (S)-coclaurine, (R)coclaurine is not methylated | Stephania delavayi |
2.1.1.140 | 0.0003 | - |
enzyme extract of cell culture, (S)-coclaurine, (R)coclaurine is not methylated | Thalictrum flavum |
2.1.1.140 | 0.00065 | - |
enzyme extract of cell culture, (S)-coclaurine, (R)coclaurine is not methylated | Thalictrum glaucum |
2.1.1.140 | 0.00066 | - |
enzyme extract of cell culture, (S)-coclaurine, (R)coclaurine is not methylated | Thalictrum dasycarpum |
2.1.1.140 | 0.0007 | - |
enzyme extract of cell culture, (S)-coclaurine, (R)coclaurine is not methylated | Corydalis vaginans |
2.1.1.140 | 0.00075 | - |
enzyme extract of cell culture, (S)-coclaurine, (R)coclaurine is not methylated | Bocconia cordata |
2.1.1.140 | 0.00077 | - |
enzyme extract of cell culture, (S)-coclaurine, (R)coclaurine is not methylated | Cocculus trilobus |
2.1.1.140 | 0.0008 | - |
enzyme extract of cell culture, (S)-coclaurine | Berberis stolonifera |
2.1.1.140 | 0.0013 | - |
enzyme extract of cell culture, (S)-coclaurine, (R)coclaurine is not methylated | Eschscholzia californica |
2.1.1.140 | 0.002 | - |
enzyme extract of cell culture, (S)-coclaurine | Berberis koetineana |
2.1.1.140 | 0.002 | - |
enzyme extract of cell culture, (S)-coclaurine | Berberis canadensis |
2.1.1.140 | 0.003 | - |
enzyme extract of cell culture, (S)-coclaurine, (R)coclaurine is not methylated | Tinospora fragosa |
2.1.1.140 | 0.0036 | - |
enzyme extract of cell culture, (S)-coclaurine | Tinospora cordifolia |
2.1.1.140 | 0.4 | - |
- |
Tinospora cordifolia |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
2.1.1.140 | (S)-coclaurine + S-adenosyl-L-methionine | - |
Eschscholzia californica | S-adenosyl-L-homocysteine + (S)-N-methylcoclaurine | - |
? | |
2.1.1.140 | (S)-coclaurine + S-adenosyl-L-methionine | - |
Lamprocapnos spectabilis | S-adenosyl-L-homocysteine + (S)-N-methylcoclaurine | - |
? | |
2.1.1.140 | (S)-coclaurine + S-adenosyl-L-methionine | - |
Fumaria officinalis | S-adenosyl-L-homocysteine + (S)-N-methylcoclaurine | - |
? | |
2.1.1.140 | (S)-coclaurine + S-adenosyl-L-methionine | - |
Berberis koetineana | S-adenosyl-L-homocysteine + (S)-N-methylcoclaurine | - |
? | |
2.1.1.140 | (S)-coclaurine + S-adenosyl-L-methionine | - |
Berberis stolonifera | S-adenosyl-L-homocysteine + (S)-N-methylcoclaurine | - |
? | |
2.1.1.140 | (S)-coclaurine + S-adenosyl-L-methionine | - |
Bocconia cordata | S-adenosyl-L-homocysteine + (S)-N-methylcoclaurine | - |
? | |
2.1.1.140 | (S)-coclaurine + S-adenosyl-L-methionine | - |
Corydalis vaginans | S-adenosyl-L-homocysteine + (S)-N-methylcoclaurine | - |
? | |
2.1.1.140 | (S)-coclaurine + S-adenosyl-L-methionine | - |
Stephania delavayi | S-adenosyl-L-homocysteine + (S)-N-methylcoclaurine | - |
? | |
2.1.1.140 | (S)-coclaurine + S-adenosyl-L-methionine | - |
Tinospora cordifolia | S-adenosyl-L-homocysteine + (S)-N-methylcoclaurine | - |
? | |
2.1.1.140 | (S)-coclaurine + S-adenosyl-L-methionine | - |
Berberis canadensis | S-adenosyl-L-homocysteine + (S)-N-methylcoclaurine | - |
? | |
2.1.1.140 | (S)-coclaurine + S-adenosyl-L-methionine | - |
Cocculus trilobus | S-adenosyl-L-homocysteine + (S)-N-methylcoclaurine | - |
? | |
2.1.1.140 | (S)-coclaurine + S-adenosyl-L-methionine | - |
Tinospora fragosa | S-adenosyl-L-homocysteine + (S)-N-methylcoclaurine | - |
? | |
2.1.1.140 | (S)-coclaurine + S-adenosyl-L-methionine | - |
Thalictrum dasycarpum | S-adenosyl-L-homocysteine + (S)-N-methylcoclaurine | - |
? | |
2.1.1.140 | (S)-coclaurine + S-adenosyl-L-methionine | - |
Thalictrum flavum | S-adenosyl-L-homocysteine + (S)-N-methylcoclaurine | - |
? | |
2.1.1.140 | (S)-coclaurine + S-adenosyl-L-methionine | - |
Thalictrum glaucum | S-adenosyl-L-homocysteine + (S)-N-methylcoclaurine | - |
? | |
2.1.1.140 | (S)-coclaurine + S-adenosyl-L-methionine | strictly stereospecific, only (S)-coclaurine is N-methylated | Tinospora cordifolia | S-adenosyl-L-homocysteine + (S)-N-methylcoclaurine | - |
? | |
2.1.1.140 | (S)-norcoclaurine + S-adenosyl-L-methionine | strictly stereospecific, only (S)-norcoclaurine is N-methylated | Tinospora cordifolia | S-adenosyl-L-homocysteine + (R)-N-methylnorcoclaurine | - |
? |
EC Number | Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|---|
2.1.1.140 | 34 | 37 | 23fold purified enzyme preparation, pH 9.0 | Tinospora cordifolia |
EC Number | pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|---|
2.1.1.140 | 8.6 | - |
narrow optimum | Tinospora cordifolia |
EC Number | pH Minimum | pH Maximum | Comment | Organism |
---|---|---|---|---|
2.1.1.140 | 6 | 9.5 | - |
Tinospora cordifolia |
EC Number | Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|---|
2.1.1.140 | 0.062 | - |
S-adenosyl-L-methionine | substrate (S)-coclaurine | Tinospora cordifolia |