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Literature summary extracted from

  • Britton, H.G.; Rubio, V.
    Carbamoyl-phosphate synthetase I. Kinetic of binding and dissociation of acetylglutamate and of activation and deactivation (1988), Eur. J. Biochem., 171, 615-622.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
6.3.4.16 acetylglutamate little activity at physiological concentrations of substrates in absence of acetylglutamate Rattus norvegicus
6.3.4.16 acetylglutamate acetylglutamate does not dissociate with each turnover of the enzyme Rattus norvegicus

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
6.3.4.16 Cs+ monovalent cation required, ATP hydrolysis is activated in the order of the series: Tl+, Cs+, Rb+, K+, Na+. Half-maximal activation at 1-2 mM Rattus norvegicus
6.3.4.16 K+ monovalent cation required, ATP hydrolysis is activated in the order of the series: Tl+, Cs+, Rb+, K+, Na+. Half-maximal activation at 1-2 mM Rattus norvegicus
6.3.4.16 Na+ monovalent cation required, ATP hydrolysis is activated in the order of the series: Tl+, Cs+, Rb+, K+, Na+ Rattus norvegicus
6.3.4.16 Rb+ monovalent cation required, ATP hydrolysis is activated in the order of the series: Tl+, Cs+, Rb+, K+, Na+. Half-maximal activation at 1-2 mM Rattus norvegicus
6.3.4.16 Tl+ monovalent cation required, ATP hydrolysis is activated in the order of the series: Tl+, Cs+, Rb+, K+, Na+. Half-maximal activation at 0.2-0.6 mM Rattus norvegicus

Organism

EC Number Organism UniProt Comment Textmining
6.3.4.16 Rattus norvegicus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
6.3.4.16 liver
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
6.3.4.16 ATP + NH4+ + CO2 + H2O
-
 Rattus norvegicus ADP + phosphate + carbamoylphosphate
-
 ?