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Literature summary extracted from

  • Caperelli, C.A.; Liu, D.
    Carbocyclic substrates for de novo purine biosynthesis. Enantiospecific synthesis and enantiospecificity of enzymatic utilization (1992), J. Biol. Chem., 267, 9783-9787.
    View publication on PubMed

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
6.3.4.13 0.00247
-
 5'-phosphoribosylglycinamide
-
 Gallus gallus
6.3.4.13 0.0064
-
 ADP
-
 Gallus gallus
6.3.4.13 0.03
-
 5'-phosphoribosylglycinamide
-
 Gallus gallus
6.3.4.13 0.04588
-
 (+/-)-carbocyclic glycinamide ribonucleotide
-
 Gallus gallus
6.3.4.13 0.54
-
 phosphate
-
 Gallus gallus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.1.2.2 10-formyltetrahydrofolate + 5-phospho-D-ribosylglycinamide Mus musculus essential enzyme in DNA synthesis, third enzyme in de novo purine biosynthesis pathway tetrahydrofolate + 5'-phosphoribosyl-N-formylglycinamide
-
 ?
2.1.2.2 10-formyltetrahydrofolate + 5-phospho-D-ribosylglycinamide Homo sapiens essential enzyme in DNA synthesis, third enzyme in de novo purine biosynthesis pathway tetrahydrofolate + 5'-phosphoribosyl-N-formylglycinamide
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.1.2.2 Homo sapiens
-
 human
-
2.1.2.2 Mus musculus
-
 mouse
-
6.3.4.13 Gallus gallus
-
-
-
6.3.5.3 Escherichia coli
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
6.3.4.13 liver
-
 Gallus gallus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.1.2.2 10-formyltetrahydrofolate + 5-phospho-D-ribosylglycinamide
-
 Mus musculus tetrahydrofolate + 5'-phosphoribosyl-N-formylglycinamide
-
 ?
2.1.2.2 10-formyltetrahydrofolate + 5-phospho-D-ribosylglycinamide
-
 Homo sapiens tetrahydrofolate + 5'-phosphoribosyl-N-formylglycinamide
-
 ?
2.1.2.2 10-formyltetrahydrofolate + 5-phospho-D-ribosylglycinamide essential enzyme in DNA synthesis, third enzyme in de novo purine biosynthesis pathway Mus musculus tetrahydrofolate + 5'-phosphoribosyl-N-formylglycinamide
-
 ?
2.1.2.2 10-formyltetrahydrofolate + 5-phospho-D-ribosylglycinamide essential enzyme in DNA synthesis, third enzyme in de novo purine biosynthesis pathway Homo sapiens tetrahydrofolate + 5'-phosphoribosyl-N-formylglycinamide
-
 ?
2.1.2.2 10-formyltetrahydrofolate + carbocyclic beta-glycinamide ribonucleotide
-
 Mus musculus tetrahydrofolate + formyl glycinamide ribonucleotide
-
 ?
2.1.2.2 10-formyltetrahydrofolate + carbocyclic beta-glycinamide ribonucleotide
-
 Homo sapiens tetrahydrofolate + formyl glycinamide ribonucleotide
-
 ?
6.3.4.13 ADP + phosphate + N1-(5-phospho-D-ribosyl)glycinamide ADP in form of MgADP- Gallus gallus ATP + 5-phospho-D-ribosylamine + glycine
-
 r
6.3.4.13 ATP + 5-phospho-D-ribosylamine + Gly
-
 Gallus gallus ADP + phosphate + N1-(5-phospho-D-ribosyl)glycinamide
-
 ?
6.3.4.13 ATP + 5-phosphoribosylamine + Gly
-
 Gallus gallus ADP + phosphate + 5-phosphoribosylglycinamide
-
 ?
6.3.4.13 ATP + carbocyclic 5-phosphoribosylamine + Gly r Gallus gallus ADP + phosphate + carbocyclic glycinamide ribonucleotide
-
 ?
6.3.5.3 ATP + 5'-phosphoribosylformylglycinamide + L-Gln + H2O
-
 Escherichia coli ADP + phosphate + 5'-phosphoribosylformylglycinamidine + L-Glu
-
 ?