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Literature summary extracted from

  • Nierlich, D.P.
    Phosphoribosylglycinamide synthetase from Aerobacter aerogenes (1978), Methods Enzymol., 51, 179-185.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
6.3.4.13 ADP
-
Klebsiella aerogenes
6.3.4.13 EDTA
-
Klebsiella aerogenes
6.3.4.13 NaF
-
Klebsiella aerogenes
6.3.4.13 PCMB
-
Klebsiella aerogenes

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
6.3.4.13 0.056
-
ATP at a Mg2+ concentration of 5.7 mM Klebsiella aerogenes
6.3.4.13 0.19
-
Gly
-
Klebsiella aerogenes

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
6.3.4.13 Mg2+ required Klebsiella aerogenes

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
6.3.4.13 ATP + 5-phosphoribosylamine + Gly Klebsiella aerogenes second step in de novo path of purine biosynthesis ?
-
?

Organism

EC Number Organism UniProt Comment Textmining
6.3.4.13 Klebsiella aerogenes
-
i.e. Klebsiella pneumoniae
-

Purification (Commentary)

EC Number Purification (Comment) Organism
6.3.4.13
-
Klebsiella aerogenes

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
6.3.4.13 1.7
-
-
Klebsiella aerogenes

Storage Stability

EC Number Storage Stability Organism
6.3.4.13 -18°C, stable for at least 1 year Klebsiella aerogenes

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
6.3.4.13 ATP + 5-phosphoribosylamine + Gly
-
Klebsiella aerogenes ADP + phosphate + 5-phosphoribosylglycinamide
-
?
6.3.4.13 ATP + 5-phosphoribosylamine + Gly second step in de novo path of purine biosynthesis Klebsiella aerogenes ?
-
?

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
6.3.4.13 7 8
-
Klebsiella aerogenes