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Literature summary extracted from

  • Rowe, P.B.; McCairns, E.; Madsen, G.; Sauer, D.; Elliott, H.
    De novo purine synthesis in avian liver. Co-purification of the enzymes and properties of the pathway (1978), J. Biol. Chem., 253, 7711-7721.
    View publication on PubMed

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
4.1.1.21 1-(5-Phosphoribosyl)-5-aminoimidazole + CO2 Pigeon enzyme of the de novo purine biosynthesis ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
4.1.1.21 Pigeon
-
-
-
6.3.2.6 Pigeon
-
-
-
6.3.4.13 Pigeon
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
4.1.1.21 copurification of the enzymes of the de novo purine biosynthetic pathway Pigeon
6.3.2.6 partial Pigeon
6.3.4.13
-
 Pigeon

Source Tissue

EC Number Source Tissue Comment Organism Textmining
4.1.1.21 liver
-
 Pigeon
-
6.3.2.6 liver
-
 Pigeon
-
6.3.4.13 liver
-
 Pigeon
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
4.1.1.21 1-(5-Phosphoribosyl)-5-aminoimidazole + CO2
-
 Pigeon 1-(5-Phosphoribosyl)-5-amino-4-imidazolecarboxylate
-
 ?
4.1.1.21 1-(5-Phosphoribosyl)-5-aminoimidazole + CO2 enzyme of the de novo purine biosynthesis Pigeon ?
-
 ?
6.3.2.6 ATP + 1-(5'-phosphoribosyl)-5-amino-4-carboxyimidazole + L-Asp
-
 Pigeon ADP + phosphate + 1-(5'-phosphoribosyl)-5-amino-4-(N-succinocarboxamide)-imidazole
-
 ?
6.3.4.13 ATP + 5-phosphoribosylamine + Gly
-
 Pigeon ADP + phosphate + 5-phosphoribosylglycinamide
-
 ?

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
6.3.4.13 50
-
-
 Pigeon

Temperature Range [°C]

EC Number Temperature Minimum [°C] Temperature Maximum [°C] Comment Organism
6.3.4.13 50 55 50°C: maximal activity, sharp fall of activity above 55°C Pigeon

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
6.3.4.13 7.5 8
-
 Pigeon

pH Range

EC Number pH Minimum pH Maximum Comment Organism
6.3.4.13 7.5 8.5 7.5-8.0: maximal activity, sharp fall of activity above pH 8.5 Pigeon