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Literature summary extracted from
- Threonine synthetase from higher plants: stimulation by S-adenosylmethionine and inhibition by cysteine (1976), Biochem. Biophys. Res. Commun., 71, 684-691.
Activating Compound
| EC Number | Activating Compound | Comment | Organism | Structure |
|---|---|---|---|---|
| 4.2.3.1 | S-adenosylmethionine | allosteric activator, 14fold increase of Vmax, 8% decrease of substrate Km at 0.5 mM | Beta vulgaris |  |
Inhibitors
| EC Number | Inhibitors | Comment | Organism | Structure |
|---|---|---|---|---|
| 4.2.3.1 | L-cysteine | stereospecific, inhibits S-adenosylmethionine activation | Beta vulgaris | |
KM Value [mM]
| EC Number | KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|---|
| 4.2.3.1 | 1.3 | 2.7 | O-phosphohomoserine | - |
Beta vulgaris | |
| 4.2.3.1 | 1.3 | 2.7 | O-phosphohomoserine | - |
Raphanus sativus | |
Natural Substrates/ Products (Substrates)
| EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 4.2.3.1 | O-phospho-L-homoserine | Beta vulgaris | involved in allocation of phosphohomoserine between cystathione and threonine pathways | ? | - |
? | |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 4.2.3.1 | Beta vulgaris | - |
var. altissima | - |
| 4.2.3.1 | Raphanus sativus | - |
- |
- |
Source Tissue
| EC Number | Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|---|
| 4.2.3.1 | leaf | - |
Beta vulgaris | - |
| 4.2.3.1 | leaf | - |
Raphanus sativus | - |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 4.2.3.1 | O-phospho-L-homoserine | involved in allocation of phosphohomoserine between cystathione and threonine pathways | Beta vulgaris | ? | - |
? | |
| 4.2.3.1 | O-phospho-L-homoserine + H2O | - |
Beta vulgaris | L-threonine + phosphate | - |
ir | |
| 4.2.3.1 | O-phospho-L-homoserine + H2O | - |
Raphanus sativus | L-threonine + phosphate | - |
ir | |
Temperature Optimum [°C]
| EC Number | Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|---|
| 4.2.3.1 | 30 | - |
enzyme assay at | Beta vulgaris |
pH Optimum
| EC Number | pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|---|
| 4.2.3.1 | 7.3 | - |
enzyme assay at | Beta vulgaris |
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Release 2023.1 (January 2023)
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