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Literature summary extracted from

  • Lomo, P.O.; Coetzer, T.H.T.; Lonsdale-Eccles, J.D.
    Characterization of a multicatalytic proteinase complex (20S proteasome) from Trypanosoma brucei brucei (1997), Immunopharmacology, 36, 285-293.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.4.25.1 chymostatin inhibits chymotrypsin-like activity Trypanosoma brucei
3.4.25.1 leupeptin inhibits trypsin-like activity Trypanosoma brucei

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
3.4.25.1 630000
-
 non-denaturing PAGE Trypanosoma brucei

Organism

EC Number Organism UniProt Comment Textmining
3.4.25.1 Trypanosoma brucei
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
3.4.25.1
-
 Trypanosoma brucei

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
3.4.25.1 7.51
-
-
 Trypanosoma brucei

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.4.25.1 benzyloxycarbonyl-Arg-Arg-7-amido-4-methylcoumarin + H2O
-
 Trypanosoma brucei ?
-
 ?
3.4.25.1 benzyloxycarbonyl-Gly-Gly-Leu-7-amido-4-methylcoumarin + H2O
-
 Trypanosoma brucei ?
-
 ?
3.4.25.1 benzyloxycarbonyl-Leu-Leu-Glu-beta-naphthylamide + H2O
-
 Trypanosoma brucei ?
-
 ?
3.4.25.1 benzyloxycarbonyl-Phe-Arg-7-amido-4-methylcoumarin + H2O
-
 Trypanosoma brucei ?
-
 ?

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
3.4.25.1 7.8
-
 chymotrypsin-like activity Trypanosoma brucei
3.4.25.1 8
-
 peptidylglutamyl peptide hydrolase activity Trypanosoma brucei
3.4.25.1 10.5
-
 trypsin-like activity Trypanosoma brucei