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Literature summary extracted from
- Enzymic properties of thermopsin (1990), J. Biol. Chem., 265, 1496-1501.
Inhibitors
| EC Number | Inhibitors | Comment | Organism | Structure |
|---|---|---|---|---|
| 3.4.23.42 | 1,2-epoxy-3-(p-nitrophenoxy)propane | - |
Sulfolobus acidocaldarius |  |
| 3.4.23.42 | acetamide | - |
Sulfolobus acidocaldarius | |
| 3.4.23.42 | diazoacetyl-DL-norleucine | - |
Sulfolobus acidocaldarius | |
| 3.4.23.42 | HgCl2 | reversible by 2-mercaptoethanol | Sulfolobus acidocaldarius | |
| 3.4.23.42 | pepstatin | - |
Sulfolobus acidocaldarius | |
| 3.4.23.42 | phenylalaninamide | - |
Sulfolobus acidocaldarius | |
| 3.4.23.42 | Urea | - |
Sulfolobus acidocaldarius | |
KM Value [mM]
| EC Number | KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|---|
| 3.4.23.42 | 0.053 | - |
Lys-Pro-Ala-Glu-Phe-(4-nitro)Phe-Ala-Leu | - |
Sulfolobus acidocaldarius | |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 3.4.23.42 | Sulfolobus acidocaldarius | - |
- |
- |
Reaction
| EC Number | Reaction | Comment | Organism | Reaction ID |
|---|---|---|---|---|
| 3.4.23.42 | similar in specificity to pepsin A preferring bulky hydrophobic amino acids in P1 and P1' | prefers large hydrophobic residues at both sides of the scissile bond | Sulfolobus acidocaldarius |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 3.4.23.42 | Bovine serum albumin + H2O | - |
Sulfolobus acidocaldarius | ? | - |
? | |
| 3.4.23.42 | glyceraldehyde-3-phosphate dehydrogenase + H2O | - |
Sulfolobus acidocaldarius | ? | - |
? | |
| 3.4.23.42 | Hemoglobin + H2O | - |
Sulfolobus acidocaldarius | ? | - |
? | |
| 3.4.23.42 | Lys-Pro-Ala-Glu-Phe-(4-nitro)Phe-Ala-Leu + H2O | - |
Sulfolobus acidocaldarius | Lys-Pro-Ala-Glu-Phe + (4-nitro)Phe-Ala-Leu | - |
? | |
| 3.4.23.42 | ovalbumin + H2O | - |
Sulfolobus acidocaldarius | ? | - |
? | |
| 3.4.23.42 | oxidized insulin B + H2O | following bonds are hydrolyzed: Leu-Val, Leu-Tyr, Phe-Phe, Phe-Tyr, Tyr-Thr | Sulfolobus acidocaldarius | ? | - |
? | |
Temperature Optimum [°C]
| EC Number | Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|---|
| 3.4.23.42 | 75 | - |
- |
Sulfolobus acidocaldarius |
pH Optimum
| EC Number | pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|---|
| 3.4.23.42 | 2 | - |
- |
Sulfolobus acidocaldarius |
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Release 2023.1 (January 2023)
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