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Literature summary extracted from

  • Keiler, K.C.; Sauer, R.T.
    Identification of active site residues of the Tsp protease (1995), J. Biol. Chem., 270, 28864-28868.
    View publication on PubMed

Protein Variants

EC Number Protein Variants Comment Organism
3.4.21.102 D369A hydrolysis of the 105 variant of N-terminal domain of lambda repressor Escherichia coli
3.4.21.102 D441A no hydrolysis of the 105 variant of N-terminal domain of lambda repressor Escherichia coli
3.4.21.102 D441N hydrolysis of the 105 variant of N-terminal domain of lambda repressor Escherichia coli
3.4.21.102 D505A hydrolysis of the 105 variant of N-terminal domain of lambda repressor Escherichia coli
3.4.21.102 E433A no hydrolysis of the 105 variant of N-terminal domain of lambda repressor Escherichia coli
3.4.21.102 E449A hydrolysis of the 105 variant of N-terminal domain of lambda repressor Escherichia coli
3.4.21.102 G375A no hydrolysis of the 105 variant of N-terminal domain of lambda repressor Escherichia coli
3.4.21.102 G376A no hydrolysis of the 105 variant of N-terminal domain of lambda repressor Escherichia coli
3.4.21.102 H19A hydrolysis of the 105 variant of N-terminal domain of lambda repressor Escherichia coli
3.4.21.102 H203A hydrolysis of the 105 variant of N-terminal domain of lambda repressor Escherichia coli
3.4.21.102 H34A hydrolysis of the 105 variant of N-terminal domain of lambda repressor Escherichia coli
3.4.21.102 H553A hydrolysis of the 105 variant of N-terminal domain of lambda repressor Escherichia coli
3.4.21.102 H60A hydrolysis of the 105 variant of N-terminal domain of lambda repressor Escherichia coli
3.4.21.102 K455A no hydrolysis of the 105 variant of N-terminal domain of lambda repressor Escherichia coli
3.4.21.102 K455R no hydrolysis of the 105 variant of N-terminal domain of lambda repressor Escherichia coli
3.4.21.102 R371A hydrolysis of the 105 variant of N-terminal domain of lambda repressor Escherichia coli
3.4.21.102 R444A hydrolysis of the 105 variant of N-terminal domain of lambda repressor Escherichia coli
3.4.21.102 S372A hydrolysis of the 105 variant of N-terminal domain of lambda repressor Escherichia coli
3.4.21.102 S428A hydrolysis of the 105 variant of N-terminal domain of lambda repressor Escherichia coli
3.4.21.102 S430A no hydrolysis of the 105 variant of N-terminal domain of lambda repressor Escherichia coli
3.4.21.102 S430C hydrolysis of the 105 variant of N-terminal domain of lambda repressor Escherichia coli
3.4.21.102 S432A hydrolysis of the 105 variant of N-terminal domain of lambda repressor Escherichia coli
3.4.21.102 T452A no hydrolysis of the 105 variant of N-terminal domain of lambda repressor Escherichia coli

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.4.21.102 Protein + H2O Escherichia coli
-
 ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
3.4.21.102 Escherichia coli P23865
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.4.21.102 Protein + H2O
-
 Escherichia coli ?
-
 ?
3.4.21.102 variant of the lambda repressor + H2O C-terminal sequence: WVAAA, endoproteolytic cleavage Escherichia coli ?
-
 ?