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Literature summary extracted from
- Prolinase and non-specific dipeptidase of human kidney (1985), Biochem. J., 231, 689-694.
Inhibitors
| EC Number | Inhibitors | Comment | Organism | Structure |
|---|---|---|---|---|
| 3.4.13.18 | p-hydroxymercuribenzoate | - |
Homo sapiens |  |
| 3.4.13.19 | p-hydroxymercuribenzoate | - |
Homo sapiens | |
| 3.4.13.19 | Pro-Ala | competitive to hydrolysis of Gly-Leu | Homo sapiens | |
KM Value [mM]
| EC Number | KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|---|
| 3.4.13.18 | 0.47 | - |
Pro-Ala | at pH 8.0 and 9.2 | Homo sapiens | |
| 3.4.13.18 | 0.79 | - |
Gly-Leu | at pH 8.0 and 9.2 | Homo sapiens | |
| 3.4.13.19 | 0.79 | - |
Gly-Leu | - |
Homo sapiens | |
Molecular Weight [Da]
| EC Number | Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|---|
| 3.4.13.18 | 100000 | - |
gel filtration | Homo sapiens |
| 3.4.13.19 | 100000 | - |
gel filtration | Homo sapiens |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 3.4.13.18 | Homo sapiens | - |
- |
- |
| 3.4.13.19 | Homo sapiens | - |
prolinase and non-specific dipeptidase in human kidney are due to a single enzyme | - |
Purification (Commentary)
| EC Number | Purification (Comment) | Organism |
|---|---|---|
| 3.4.13.18 | - |
Homo sapiens |
| 3.4.13.19 | - |
Homo sapiens |
Source Tissue
| EC Number | Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|---|
| 3.4.13.18 | kidney | - |
Homo sapiens | - |
| 3.4.13.19 | kidney | - |
Homo sapiens | - |
Specific Activity [micromol/min/mg]
| EC Number | Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|---|
| 3.4.13.18 | additional information | - |
- |
Homo sapiens |
| 3.4.13.19 | additional information | - |
- |
Homo sapiens |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 3.4.13.18 | Gly-Leu + H2O | - |
Homo sapiens | Gly + Leu | - |
? | |
| 3.4.13.18 | Pro-Ala + H2O | - |
Homo sapiens | Pro + Ala | - |
? | |
| 3.4.13.18 | Pro-Leu + H2O | - |
Homo sapiens | Pro + Leu | - |
? | |
| 3.4.13.19 | Gly-Leu + H2O | best substrate | Homo sapiens | Gly + Leu | - |
? | |
Temperature Stability [°C]
| EC Number | Temperature Stability Minimum [°C] | Temperature Stability Maximum [°C] | Comment | Organism |
|---|---|---|---|---|
| 3.4.13.18 | 53 | - |
pH 7.4, about 65% loss of activity after 15 min | Homo sapiens |
| 3.4.13.19 | 53 | - |
12 min, about 50% loss of activity | Homo sapiens |
pH Optimum
| EC Number | pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|---|
| 3.4.13.18 | additional information | - |
pI: 5.4 | Homo sapiens |
pI Value
| EC Number | Organism | Comment | pI Value Maximum | pI Value |
|---|---|---|---|---|
| 3.4.13.19 | Homo sapiens | - |
- |
5.4 |
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