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Literature summary extracted from

  • Lenney, J.F.
    Separation and characterization of two carnosine-splitting cytosolic dipeptidases from hog kidney (carnosinase and non-specific dipeptidase) (1990), Biol. Chem. Hoppe-Seyler, 371, 433-440.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
3.4.13.18 DTT activates Sus scrofa

General Stability

EC Number General Stability Organism
3.4.13.18 DTT stabilizes Sus scrofa
3.4.13.18 Mn2+ stabilizes Sus scrofa

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.4.13.18 amastatin
-
 Sus scrofa
3.4.13.18 bestatin
-
 Sus scrofa
3.4.13.18 Gly-Leu competitive inhibitor of L-Ala-Gly hydrolysis Sus scrofa
3.4.13.18 leucine
-
 Sus scrofa
3.4.13.18 p-hydroxymercuribenzoate
-
 Sus scrofa

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
3.4.13.18 5
-
 carnosine
-
 Sus scrofa

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
3.4.13.18 cytosol
-
 Sus scrofa 5829
-

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
3.4.13.18 Mn2+ required Sus scrofa

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
3.4.13.18 70000
-
 gel filtration Sus scrofa

Organism

EC Number Organism UniProt Comment Textmining
3.4.13.18 Sus scrofa
-
 hog
-

Purification (Commentary)

EC Number Purification (Comment) Organism
3.4.13.18
-
 Sus scrofa

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.4.13.18 brain
-
 Sus scrofa
-
3.4.13.18 kidney
-
 Sus scrofa
-
3.4.13.18 liver
-
 Sus scrofa
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.4.13.18 Ala-Ala + H2O
-
 Sus scrofa Ala + Ala
-
 ?
3.4.13.18 Ala-Leu + H2O
-
 Sus scrofa Ala + Leu
-
 ?
3.4.13.18 carnosine + H2O
-
 Sus scrofa ?
-
 ?
3.4.13.18 Gly-Gly + H2O
-
 Sus scrofa Gly + Gly
-
 ?
3.4.13.18 Gly-His + H2O
-
 Sus scrofa Gly + His
-
 ?
3.4.13.18 Gly-Leu + H2O
-
 Sus scrofa Gly + Leu
-
 ?
3.4.13.18 His-Ala + H2O
-
 Sus scrofa His + Ala
-
 ?
3.4.13.18 Leu-Leu + H2O
-
 Sus scrofa Leu + Leu
-
 ?
3.4.13.18 additional information not: anserine Sus scrofa ?
-
 ?
3.4.13.18 additional information not: Gly-Gly-Gly Sus scrofa ?
-
 ?
3.4.13.18 additional information not: N-Ac-Met Sus scrofa ?
-
 ?
3.4.13.18 additional information not: homocarnosine Sus scrofa ?
-
 ?
3.4.13.18 additional information not: beta-Ala-Lys Sus scrofa ?
-
 ?
3.4.13.18 additional information not: Gly-His-Gly Sus scrofa ?
-
 ?
3.4.13.18 Pro-Ala + H2O
-
 Sus scrofa Pro + Ala
-
 ?
3.4.13.18 Pro-Leu + H2O
-
 Sus scrofa Pro + Leu
-
 ?

Temperature Stability [°C]

EC Number Temperature Stability Minimum [°C] Temperature Stability Maximum [°C] Comment Organism
3.4.13.18 additional information
-
 Mn2+ stabilizes against heat inactivation Sus scrofa
3.4.13.18 additional information
-
 DTT stabilizes against heat inactivation Sus scrofa

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
3.4.13.18 additional information
-
 pI: 5.0 Sus scrofa
3.4.13.18 8.8
-
 carnosine Sus scrofa

pH Stability

EC Number pH Stability pH Stability Maximum Comment Organism
3.4.13.18 7.3 8.3 maximal stability at 50°C for 30 min Sus scrofa