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Literature summary extracted from
- Adenosine analogues as inhibitors or inactivators of S-adenosylhomocysteine hydrolase from bovine pancreas (1993), J. Enzyme Inhib., 7, 159-167.
No PubMed abstract available
Application
| EC Number | Application | Comment | Organism |
|---|---|---|---|
| 3.13.2.1 | medicine | antiviral drug design | Bos taurus |
| 3.13.2.1 | medicine | antineoplastic drug design | Bos taurus |
Inhibitors
| EC Number | Inhibitors | Comment | Organism | Structure |
|---|---|---|---|---|
| 3.13.2.1 | 2'-deoxyadenosine | - |
Bos taurus |  |
| 3.13.2.1 | 2-chloroadenosine | - |
Bos taurus | |
| 3.13.2.1 | 3-deaza-(+/-)-aristeromycin | - |
Bos taurus | |
| 3.13.2.1 | 3-deazaadenosine | - |
Bos taurus | |
| 3.13.2.1 | Inosine | - |
Bos taurus | |
| 3.13.2.1 | nebularine | - |
Bos taurus | |
| 3.13.2.1 | tubercidin | - |
Bos taurus | |
KM Value [mM]
| EC Number | KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|---|
| 3.13.2.1 | 0.008 | - |
adenosine | - |
Bos taurus | |
| 3.13.2.1 | 0.042 | - |
S-adenosyl-L-homocysteine | - |
Bos taurus | |
Natural Substrates/ Products (Substrates)
| EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 3.13.2.1 | S-adenosyl-L-homocysteine + H2O | Bos taurus | - |
adenosine + L-homocysteine | - |
r | |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 3.13.2.1 | Bos taurus | - |
- |
- |
Purification (Commentary)
| EC Number | Purification (Comment) | Organism |
|---|---|---|
| 3.13.2.1 | to homogeneity | Bos taurus |
Reaction
| EC Number | Reaction | Comment | Organism | Reaction ID |
|---|---|---|---|---|
| 3.13.2.1 | S-adenosyl-L-homocysteine + H2O = L-homocysteine + adenosine | reaction equilibrium is in vitro strongly in direction of synthesis of S-adenosyl-L-homocysteine | Bos taurus |
Source Tissue
| EC Number | Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|---|
| 3.13.2.1 | pancreas | - |
Bos taurus | - |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 3.13.2.1 | DL-homocysteine + adenosine | - |
Bos taurus | S-adenosyl-DL-homocysteine | - |
r | |
| 3.13.2.1 | S-adenosyl-L-homocysteine + H2O | - |
Bos taurus | adenosine + L-homocysteine | - |
r | |
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