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Literature summary extracted from
- Effects of novel anti-viral adenosine analogues on the activity of S-adenosylhomocysteine hydrolase from human liver (1994), Biochem. Pharmacol., 48, 897-903.
Application
| EC Number | Application | Comment | Organism |
|---|---|---|---|
| 3.13.2.1 | medicine | antiviral drug design | Homo sapiens |
Inhibitors
| EC Number | Inhibitors | Comment | Organism | Structure |
|---|---|---|---|---|
| 3.13.2.1 | 1,2,4,triazole-3-carboxamide riboside | ribavirin | Homo sapiens |  |
| 3.13.2.1 | 2'-deoxyadenosine | - |
Homo sapiens | |
| 3.13.2.1 | 2'3'-dideoxyadenosine | - |
Homo sapiens | |
| 3.13.2.1 | 2-chloroadenosine | - |
Homo sapiens | |
| 3.13.2.1 | 3'-deoxyadenosine | - |
Homo sapiens | |
| 3.13.2.1 | 5'-deoxy,5'-methylthioadenosine | - |
Homo sapiens | |
| 3.13.2.1 | 5'-iodo-5'-deoxyadenosine | - |
Homo sapiens | |
| 3.13.2.1 | 5-amino-4-imidazole carboxamide riboside | - |
Homo sapiens | |
| 3.13.2.1 | 9-beta-D-arabinofuranosyladenine | - |
Homo sapiens | |
| 3.13.2.1 | adenosylornithine | sinefungin | Homo sapiens | |
| 3.13.2.1 | neplanocin A | - |
Homo sapiens | |
| 3.13.2.1 | S-adenosyl-L-methionine | - |
Homo sapiens | |
| 3.13.2.1 | tubercidin | - |
Homo sapiens | |
KM Value [mM]
| EC Number | KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|---|
| 3.13.2.1 | 0.032 | - |
adenosine | - |
Homo sapiens | |
Localization
| EC Number | Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|---|
| 3.13.2.1 | cytosol | - |
Homo sapiens | 5829 | - |
Molecular Weight [Da]
| EC Number | Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|---|
| 3.13.2.1 | 190000 | - |
gel filtration | Homo sapiens |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 3.13.2.1 | Homo sapiens | - |
- |
- |
Purification (Commentary)
| EC Number | Purification (Comment) | Organism |
|---|---|---|
| 3.13.2.1 | partial, 500fold | Homo sapiens |
Source Tissue
| EC Number | Source Tissue | Comment | Organism | Textmining |
|---|
Specific Activity [micromol/min/mg]
| EC Number | Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|---|
| 3.13.2.1 | additional information | - |
- |
Homo sapiens |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 3.13.2.1 | DL-homocysteine + adenosine | - |
Homo sapiens | S-adenosyl-DL-homocysteine | - |
? | |
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Release 2023.1 (January 2023)
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