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Literature summary extracted from
- S-Adenosylhomocysteine hydrolase from rat liver. Purification and some properties (1981), J. Biol. Chem., 256, 1631-1635.
Inhibitors
| EC Number | Inhibitors | Comment | Organism | Structure |
|---|---|---|---|---|
| 3.13.2.1 | bisulfite | reversible | Rattus norvegicus |  |
| 3.13.2.1 | DL-homocysteine | competitive | Rattus norvegicus | |
KM Value [mM]
| EC Number | KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|---|
| 3.13.2.1 | 0.00105 | - |
adenosine | - |
Rattus norvegicus | |
| 3.13.2.1 | 0.0152 | - |
S-adenosyl-L-homocysteine | - |
Rattus norvegicus | |
| 3.13.2.1 | 0.1548 | - |
DL-homocysteine | - |
Rattus norvegicus | |
Molecular Weight [Da]
| EC Number | Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|---|
| 3.13.2.1 | 47000 | - |
4 * 47000, SDS-PAGE, probably homomeric | Rattus norvegicus |
| 3.13.2.1 | 188000 | - |
gel filtration | Rattus norvegicus |
| 3.13.2.1 | 190000 | - |
sedimentation equilibrium | Rattus norvegicus |
Natural Substrates/ Products (Substrates)
| EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 3.13.2.1 | S-adenosyl-L-homocysteine + H2O | Rattus norvegicus | - |
adenosine + L-homocysteine | - |
r | |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 3.13.2.1 | Rattus norvegicus | - |
Wistar rats | - |
Purification (Commentary)
| EC Number | Purification (Comment) | Organism |
|---|---|---|
| 3.13.2.1 | to homogeneity | Rattus norvegicus |
Source Tissue
| EC Number | Source Tissue | Comment | Organism | Textmining |
|---|
Specific Activity [micromol/min/mg]
| EC Number | Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|---|
| 3.13.2.1 | 0.77 | - |
- |
Rattus norvegicus |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 3.13.2.1 | DL-homocysteine + 3-deazaadenosine | - |
Rattus norvegicus | ? | - |
r | |
| 3.13.2.1 | DL-homocysteine + adenosine | - |
Rattus norvegicus | S-adenosyl-DL-homocysteine | - |
r | |
| 3.13.2.1 | S-adenosyl-L-homocysteine + H2O | - |
Rattus norvegicus | adenosine + L-homocysteine | - |
r | |
Subunits
| EC Number | Subunits | Comment | Organism |
|---|---|---|---|
| 3.13.2.1 | tetramer | 4 * 47000, SDS-PAGE, probably homomeric | Rattus norvegicus |
pH Optimum
| EC Number | pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|---|
| 3.13.2.1 | 6.4 | 7.2 | hydrolysis of S-adenosyl-L-homocysteine | Rattus norvegicus |
| 3.13.2.1 | 7.8 | - |
synthesis of S-adenosyl-L-homocysteine | Rattus norvegicus |
pH Range
| EC Number | pH Minimum | pH Maximum | Comment | Organism |
|---|---|---|---|---|
| 3.13.2.1 | additional information | - |
- |
Rattus norvegicus |
Cofactor
| EC Number | Cofactor | Comment | Organism | Structure |
|---|---|---|---|---|
| 3.13.2.1 | NAD+ | - |
Rattus norvegicus | |
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