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Literature summary extracted from

  • Beaulieu, J.F.; Weiser, M.M.; Herrera, L.; Quaroni, A.
    Detection and characterization of sucrase-isomaltase in adult human colon and in colonic polyps (1990), Gastroenterology, 98, 1467-1477.
    View publication on PubMed

Application

EC Number Application Comment Organism
3.2.1.48 medicine sucrase-isomaltase SI is a marker enzyme of the absorptive villose cells in adult small intestine, human intestinal sucrase-isomaltase help develop a specific inhibitor of sucrase, to retard the absorption of sucrose in the intestinal tract of diabetic patients Homo sapiens

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
3.2.1.10 brush border brush-border membrane Homo sapiens 5903
-

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
3.2.1.10 148000
-
 isomaltase in adult jejunum, SDS-PAGE Homo sapiens
3.2.1.10 150000
-
 isomaltase in adult colon, SDS-PAGE Homo sapiens
3.2.1.48 220000
-
 ultracentrifugation analysis, mature complex precursor Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.2.1.48 maltose + H2O Homo sapiens
-
 2 glucose
-
 ?
3.2.1.48 sucrose + H2O Homo sapiens
-
 D-glucose + D-fructose
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
3.2.1.10 Homo sapiens
-
-
-
3.2.1.48 Homo sapiens
-
 sucrase-isomaltase in adult human colon and colonic polyps
-

Posttranslational Modification

EC Number Posttranslational Modification Comment Organism
3.2.1.10 proteolytic modification pro-sucrase-isomaltase precursor, complex glycosylated sucrase-isomaltase precursor, high-mannose sucrase-isomaltase precursor Homo sapiens

Purification (Commentary)

EC Number Purification (Comment) Organism
3.2.1.48
-
 Homo sapiens

Reaction

EC Number Reaction Comment Organism Reaction ID
3.2.1.10 alpha-D-glucopyranosyl-(1-4)-[alpha-D-glucopyranosyl-(1-6)]-alpha-D-glucopyranosyl-(1-4)-alpha-D-glucopyranosyl-(1-4)-alpha-D-glucopyranose + H2O = alpha-D-glucopyranosyl-(1-4)-alpha-D-glucopyranosyl-(1-4)-alpha-D-glucopyranosyl-(1-4)-alpha-D-glucopyranose + D-glucose enzyme from intestinal mucosa also catalyzes the reaction of sucrase alpha-glucosidase, EC 3.2.1.48 Homo sapiens
a

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.2.1.10 colon apical region of normal crypt cells Homo sapiens
-
3.2.1.10 colon polyp Homo sapiens
-
3.2.1.10 colonic adenocarcinoma cell primary and metastatic Homo sapiens
-
3.2.1.10 small intestine
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.2.1.10 palatinose + H2O
-
 Homo sapiens D-glucose + fructose
-
 ?
3.2.1.48 maltose + H2O
-
 Homo sapiens 2 glucose
-
 ?
3.2.1.48 sucrose + H2O
-
 Homo sapiens D-glucose + D-fructose
-
 ?

Subunits

EC Number Subunits Comment Organism
3.2.1.48 dimer
-
 Homo sapiens

Synonyms

EC Number Synonyms Comment Organism
3.2.1.10 isomaltase
-
 Homo sapiens
3.2.1.10 sucrase-isomaltase
-
 Homo sapiens