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Literature summary extracted from

  • Hauri, H.P.; Quaroni, A.; Isselbacher, K.J.
    Biogenesis of intestinal plasma membrane: posttranslational route and cleavage of sucrase-isomaltase (1979), Proc. Natl. Acad. Sci. USA, 76, 5183-5186.
    View publication on PubMedView publication on EuropePMC

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
3.2.1.10 microvillus
-
 Rattus norvegicus 5902
-

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
3.2.1.48 140000
-
 1 * 140000 - 160000 + 1 * 140000 -160000 2 large subunits, EC 3.2.1.48 and EC 3.2.1.10, functional dimer, SDS-PAGE Rattus rattus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.2.1.48 maltose + H2O Rattus rattus
-
 2 glucose
-
 ?
3.2.1.48 sucrose + H2O Rattus rattus
-
 D-glucose + D-fructose
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
3.2.1.10 Rattus norvegicus
-
-
-
3.2.1.48 Rattus rattus
-
 sucrase-isomaltase synthesized as a one-chain polypeptide, precursor that is split into the subunits after its transfer to the microvillus membrane
-

Posttranslational Modification

EC Number Posttranslational Modification Comment Organism
3.2.1.10 glycoprotein
-
 Rattus norvegicus
3.2.1.10 proteolytic modification
-
 Rattus norvegicus

Reaction

EC Number Reaction Comment Organism Reaction ID
3.2.1.10 alpha-D-glucopyranosyl-(1-4)-[alpha-D-glucopyranosyl-(1-6)]-alpha-D-glucopyranosyl-(1-4)-alpha-D-glucopyranosyl-(1-4)-alpha-D-glucopyranose + H2O = alpha-D-glucopyranosyl-(1-4)-alpha-D-glucopyranosyl-(1-4)-alpha-D-glucopyranosyl-(1-4)-alpha-D-glucopyranose + D-glucose enzyme from intestinal mucosa also catalyzes the reaction of sucrase alpha-glucosidase, EC 3.2.1.48 Rattus norvegicus
a

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.2.1.10 small intestine
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.2.1.10 isomaltosaccharides + H2O n = 2, isomaltose Rattus norvegicus D-glucose
-
 ?
3.2.1.10 isomaltose + H2O
-
 Rattus norvegicus 2 D-glucose
-
 ?
3.2.1.10 maltose + H2O
-
 Rattus norvegicus 2 D-glucose
-
 ?
3.2.1.48 maltose + H2O
-
 Rattus rattus 2 glucose
-
 ?
3.2.1.48 sucrose + H2O
-
 Rattus rattus D-glucose + D-fructose
-
 ?

Subunits

EC Number Subunits Comment Organism
3.2.1.48 dimer 1 * 140000 - 160000 + 1 * 140000 -160000 2 large subunits, EC 3.2.1.48 and EC 3.2.1.10, functional dimer, SDS-PAGE Rattus rattus

Synonyms

EC Number Synonyms Comment Organism
3.2.1.10 dextrin 6-alpha-D-glucanohydrolase
-
 Rattus norvegicus
3.2.1.10 sucrase-isomaltase
-
 Rattus norvegicus