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Literature summary extracted from

  • Fabbro, D.; Grabowski, G.A.
    Human acid beta-glucosidase. Use of inhibitory and activating monoclonal antibodies to investigate the enzyme's catalytic mechanism and saposin A and C binding sites (1991), J. Biol. Chem., 266, 15021-15027.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
3.2.1.45 monoclonal antibody no. 122 mimicking the effect of saposin C Homo sapiens
3.2.1.45 saposin-A sphingolipid activator protein, only in synergy with saposin-C Homo sapiens
3.2.1.45 saposin-C sphingolipid activator protein, SAP-2 Homo sapiens

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.2.1.45 (1R,2R,3S,4S,5R,6S)-7-oxabicyclo[4.1.0]heptane-2,3,4,5-tetrol
-
 Homo sapiens
3.2.1.45 monoclonal antibodies 100% inhibition with F1 and F2, 60% inhibition with no. 61 Homo sapiens
3.2.1.45 N-dodecyl-1-deoxynojirimycin
-
 Homo sapiens
3.2.1.45 N-tetradecyl-1-deoxynojirimycin
-
 Homo sapiens
3.2.1.45 N-tetradecylglycosylamine
-
 Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.2.1.45 glucocerebroside + H2O Homo sapiens
-
 glucose + ceramide
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
3.2.1.45 Homo sapiens
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
3.2.1.45
-
 Homo sapiens

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.2.1.45 placenta
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.2.1.45 4-methylumbelliferyl-beta-D-glucopyranoside + H2O
-
 Homo sapiens methylumbelliferone + glucose
-
 ?
3.2.1.45 glucocerebroside + H2O
-
 Homo sapiens glucose + ceramide
-
 ?