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Literature summary extracted from

  • Aerts, J.M.; Sa Miranda, M.C.; Brouwer-Kelder, E.M.; Van Weely, S.; Barranger, J.A.; Tager, J.M.
    Conditions affecting the activity of glucocerebrosidase purified from spleens of control subjects and patients with type 1 Gaucher disease (1990), Biochim. Biophys. Acta, 1041, 55-63.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
3.2.1.45 phosphatidylserine
-
 Homo sapiens
3.2.1.45 saposin-C sphingolipid activator protein, SAP-2 Homo sapiens
3.2.1.45 sodium taurocholate
-
 Homo sapiens

Application

EC Number Application Comment Organism
3.2.1.45 medicine Gaucher disease, sphingolipoidose Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.2.1.45 glucocerebroside + H2O Homo sapiens
-
 glucose + ceramide
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
3.2.1.45 Homo sapiens
-
 normal and Gaucher disease enzyme
-

Purification (Commentary)

EC Number Purification (Comment) Organism
3.2.1.45
-
 Homo sapiens

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.2.1.45 spleen
-
 Homo sapiens
-

Storage Stability

EC Number Storage Stability Organism
3.2.1.45 -20°C, pH 6, 90% ethylene glycol, 20 days, no loss of activity Homo sapiens

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.2.1.45 4-methylumbelliferyl-beta-D-glucopyranoside + H2O
-
 Homo sapiens methylumbelliferone + glucose
-
 ?
3.2.1.45 glucocerebroside + H2O
-
 Homo sapiens glucose + ceramide
-
 ?