Literature summary extracted from

Tager, J.M.; Aerts, J.M.F.G.; Jonsson, L.M.V.; Murray, G.J.; van Weeley, S.; Strijland, A.; Ginns, E.I.; Reuser, A.J.J.; Schram, A.W.; Barranger, J.A.
Molecular forms, biosynthesis and maturation of glucocerebrosidase, a membrane-associated lysosomal enzyme deficient in Gaucher disease (1986), NATO ASI Ser. A, Life Sci., 116, 735-745.

No PubMed abstract available

Activating Compound

EC Number	Activating Compound	Comment	Organism	Structure
3.2.1.45	glycoprotein	heat-stable	Homo sapiens
3.2.1.45	sodium taurocholate	-	Homo sapiens

Localization

EC Number	Localization	Comment	Organism	GeneOntology No.	Textmining
3.2.1.45	lysosome	-	Homo sapiens	5764	-
3.2.1.45	membrane	-	Homo sapiens	16020	-

Molecular Weight [Da]

EC Number	Molecular Weight [Da]	Molecular Weight Maximum [Da]	Comment	Organism
3.2.1.45	52000	-	after deglycosylation, SDS-PAGE	Homo sapiens
3.2.1.45	59000	-	3 forms, 66000 Da and 62500 Da, absent in Gaucher disease patients, gel filtration, SDS-PAGE	Homo sapiens
3.2.1.45	62500	-	3 forms, 66000 Da and 59000 Da, gel filtration, SDS-PAGE	Homo sapiens
3.2.1.45	66000	-	3 forms, 62500 Da and 59000 Da, gel filtration, SDS-PAGE	Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number	Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
3.2.1.45	glucocerebroside + H2O	Homo sapiens	-	glucose + ceramide	-	?

Organism

EC Number	Organism	UniProt	Comment	Textmining
3.2.1.45	Homo sapiens	-	overview	-

Posttranslational Modification

EC Number	Posttranslational Modification	Comment	Organism
3.2.1.45	glycoprotein	-	Homo sapiens

Source Tissue

EC Number	Source Tissue	Comment	Organism	Textmining
3.2.1.45	brain	-	Homo sapiens	-
3.2.1.45	fibroblast	skin fibroblasts in culture	Homo sapiens	-
3.2.1.45	kidney	-	Homo sapiens	-
3.2.1.45	liver	-	Homo sapiens	-
3.2.1.45	placenta	-	Homo sapiens	-
3.2.1.45	spleen	-	Homo sapiens	-
3.2.1.45	urine	-	Homo sapiens	-

Substrates and Products (Substrate)

EC Number	Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
3.2.1.45	4-methylumbelliferyl-beta-D-glucopyranoside + H2O	-	Homo sapiens	methylumbelliferone + glucose	-	?
3.2.1.45	glucocerebroside + H2O	-	Homo sapiens	glucose + ceramide	-	?

Subunits

EC Number	Subunits	Comment	Organism
3.2.1.45	monomer	in tissues: monomer or aggregate, interconvertible	Homo sapiens

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Release 2023.1 (January 2023)