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Literature summary extracted from

  • Pentchev, P.G.; Brady, R.O.; Hibbert, S.R.; Gal, A.E.; Shapiro, D.
    Isolation and characterization of glucocerebrosidase from human placental tissue (1973), J. Biol. Chem., 248, 5256-5261.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
3.2.1.45 heat-stable factor
-
Homo sapiens

General Stability

EC Number General Stability Organism
3.2.1.45 dithiothreitol stabilizes in later stages of chromatographic separation Homo sapiens
3.2.1.45 glycerol stabilizes in later stages of chromatographic separation Homo sapiens

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
3.2.1.45 0.65
-
beta-D-glucocerebroside
-
Homo sapiens

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
3.2.1.45 60000
-
gel filtration, SDS-PAGE Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.2.1.45 glucocerebroside + H2O Homo sapiens
-
glucose + ceramide
-
?

Organism

EC Number Organism UniProt Comment Textmining
3.2.1.45 Homo sapiens
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.2.1.45 placenta
-
Homo sapiens
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
3.2.1.45 16.6
-
-
Homo sapiens

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.2.1.45 4-methylumbelliferyl-beta-D-glucopyranoside + H2O
-
Homo sapiens methylumbelliferone + glucose
-
?
3.2.1.45 4-nitrophenyl beta-D-glucopyranoside + H2O
-
Homo sapiens 4-nitrophenol + D-glucopyranose
-
?
3.2.1.45 glucocerebroside + H2O
-
Homo sapiens glucose + ceramide
-
?

Subunits

EC Number Subunits Comment Organism
3.2.1.45 tetramer 4 * 60000, SDS-PAGE Homo sapiens

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
3.2.1.45 5
-
addition of heat-stable factor shifts pH-optimum for hydrolysis of methylumbelliferyl-beta-D-glucose from 6.5 to 5.0 Homo sapiens
3.2.1.45 6 6.6
-
Homo sapiens