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Literature summary extracted from

  • Osiecki-Newman, K.; Fabbro, D.; Legler, G.; Desnick, R.J.; Grabowski, G.A.
    Human acid beta-glucosidase: use of inhibitors, alternative substrates and amphiphiles to investigate the properties of the normal and Gaucher disease active sites (1987), Biochim. Biophys. Acta, 915, 87-100.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.2.1.45 1-deoxynojirimycin
-
 Homo sapiens
3.2.1.45 alkyl amines
-
 Homo sapiens
3.2.1.45 Alkyl beta-glucosides
-
 Homo sapiens
3.2.1.45 N-butyl-1-deoxynojirimycin
-
 Homo sapiens
3.2.1.45 N-decyl-1-deoxynojirimycin
-
 Homo sapiens
3.2.1.45 N-dodecyl-1-deoxynojirimycin
-
 Homo sapiens
3.2.1.45 N-methyl-1-deoxynojirimycin
-
 Homo sapiens

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
3.2.1.45 0.014
-
 D-glucosyl-N-methylsphingosine
-
 Homo sapiens
3.2.1.45 0.02
-
 D-glucosyl-N-propylsphingosine
-
 Homo sapiens
3.2.1.45 0.028
-
 stearylglucosyl ceramide
-
 Homo sapiens
3.2.1.45 0.03
-
 6(N-methyl-N-(7-nitrobenz-2-oxa-1,3-diazol-4-yl))aminohexanoyl-2-N-sphingosyl 1-O-beta-D-glucoside
-
 Homo sapiens
3.2.1.45 0.032
-
 D-glucosyl-N-ethylsphingosine
-
 Homo sapiens
3.2.1.45 0.033
-
 D-glucosyl-N-octylsphingosine
-
 Homo sapiens
3.2.1.45 0.034
-
 palmitylglucosyl ceramide
-
 Homo sapiens
3.2.1.45 0.042
-
 D-glucosyl-N-butylsphingosine
-
 Homo sapiens
3.2.1.45 0.05
-
 12(N-methyl-N-(7-nitrobenz-2-oxa-1,3-diazol-4-yl))aminohexyl-2-N-sphingosyl 1-O-beta-D-glucoside
-
 Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.2.1.45 glucocerebroside + H2O Homo sapiens
-
 glucose + ceramide
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
3.2.1.45 Homo sapiens
-
 normal and Gaucher disease enzyme
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.2.1.45 placenta
-
 Homo sapiens
-
3.2.1.45 spleen
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.2.1.45 12(N-methyl-N-(7-nitrobenz-2-oxa-1,3-diazol-4-yl))aminododecanoyl-2-N-sphingosyl 1-O-beta-D-glucoside + H2O
-
 Homo sapiens D-glucose + 12(N-methyl-N-(7-nitrobenz-2-oxa-1,3-diazol-4-yl))aminododecanoyl-2-N-sphingosine
-
 ?
3.2.1.45 6(N-methyl-N-(7-nitrobenz-2-oxa-1,3-diazol-4-yl))aminohexyl-2-N-sphingosyl 1-O-beta-D-glucoside + H2O NBD-glucocerebroside Homo sapiens D-glucose + 6(N-methyl-N-(7-nitrobenz-2-oxa-1,3-diazol-4-yl))aminohexyl-2-N-sphingosine
-
 ?
3.2.1.45 D-glucosyl-N-butylsphingosine + H2O
-
 Homo sapiens D-glucose + N-butylsphingosine
-
 ?
3.2.1.45 D-glucosyl-N-ethylsphingosine + H2O
-
 Homo sapiens D-glucose + N-ethylsphingosine
-
 ?
3.2.1.45 D-glucosyl-N-methylsphingosine + H2O
-
 Homo sapiens D-glucose + N-methylsphingosine
-
 ?
3.2.1.45 D-glucosyl-N-octylsphingosine + H2O
-
 Homo sapiens D-glucose + N-octylsphingosine
-
 ?
3.2.1.45 D-glucosyl-N-propylsphingosine + H2O
-
 Homo sapiens D-glucose + N-propylsphingosine
-
 ?
3.2.1.45 glucocerebroside + H2O
-
 Homo sapiens glucose + ceramide
-
 ?
3.2.1.45 N-stearoylglucosyl ceramide + H2O
-
 Homo sapiens D-glucose + stearoylceramide
-
 ?
3.2.1.45 palmitylglucosyl ceramide + H2O
-
 Homo sapiens D-glucose + palmitylceramide
-
 ?
3.2.1.45 stearylglucosyl ceramide + H2O
-
 Homo sapiens D-glucose + stearylceramide
-
 ?