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Literature summary extracted from

  • Porwoll, S.; Fuchs, H.; Tauber, R.
    Characterization of a soluble class I alpha-mannosidase in human serum (1999), FEBS Lett., 449, 175-178.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.2.1.24 1-deoxymannojirimicin complete inhibition at 1 mM Homo sapiens
3.2.1.24 EDTA complete inhibition at 20 mM, activity recovered in the presence of Ca2+ Homo sapiens
3.2.1.113 1-deoxymannojirimycin
-
 Homo sapiens
3.2.1.113 additional information no inhibition by swainsonine Homo sapiens

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
3.2.1.113 Ca2+ requirement Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.2.1.24 Man9GlcNAc2 + H2O Homo sapiens involved in N-glycan processing to form oligomannosidic glycans during glycoprotein biosynthesis, cleaves three of the four alpha-1,2-mannosidic linkages Man5GlcNAc2 + Man6GlcNAc2 + Man7GlcNAc2 + Man8GlcNAc2 + alpha-D-mannopyranose major product: Man6GlcNAc2 ?

Organism

EC Number Organism UniProt Comment Textmining
3.2.1.24 Homo sapiens
-
-
-
3.2.1.113 Homo sapiens
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.2.1.24 serum
-
 Homo sapiens
-
3.2.1.113 serum
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.2.1.24 Man9GlcNAc2 + H2O involved in N-glycan processing to form oligomannosidic glycans during glycoprotein biosynthesis, cleaves three of the four alpha-1,2-mannosidic linkages Homo sapiens Man5GlcNAc2 + Man6GlcNAc2 + Man7GlcNAc2 + Man8GlcNAc2 + alpha-D-mannopyranose major product: Man6GlcNAc2 ?
3.2.1.113 Manalpha(1-2)Manalpha(1-6)(Manalpha(1-2)Manalpha(1-3))Manalpha(1-6)Manalpha(1-2)Manalpha(1-2)Manalpha(1-3)Manbeta(1-4)GlcNAc + 4 H2O
-
 Homo sapiens (Man)5GlcNAc + 4 D-mannose products are Man5-8GlcNAc, with Man6GlcNAc being major product ?

Synonyms

EC Number Synonyms Comment Organism
3.2.1.24 alpha 1,2-mannosidase
-
 Homo sapiens

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
3.2.1.24 6
-
-
 Homo sapiens

pH Stability

EC Number pH Stability pH Stability Maximum Comment Organism
3.2.1.24 7 7.5 30-64% remaining activity Homo sapiens