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Literature summary extracted from

  • Fluharty, A.L.; Edmond, J.
    Arylsulfatases A and B from human liver (1978), Methods Enzymol., 50, 537-547.
    View publication on PubMed

General Stability

EC Number General Stability Organism
3.1.6.8 bovine serum albumin stabilizes Homo sapiens

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.1.6.8 CN-
-
 Homo sapiens
3.1.6.8 PO43-
-
 Homo sapiens
3.1.6.8 SO32-
-
 Homo sapiens
3.1.6.8 SO42-
-
 Homo sapiens
3.1.6.8 thiol reagents
-
 Homo sapiens

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
3.1.6.8 lysosome
-
 Homo sapiens 5764
-

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
3.1.6.8 49000
-
 1 * 49000, 1 * 55000, SDS-PAGE Homo sapiens
3.1.6.8 49000
-
 aggregation to tetramer at higher concentrations around pH 5, 2 * 49000, 2 * 55000 Homo sapiens
3.1.6.8 55000
-
 1 * 49000, 1 * 55000, SDS-PAGE Homo sapiens
3.1.6.8 55000
-
 aggregation to tetramer at higher concentrations around pH 5, 2 * 49000, 2 * 55000 Homo sapiens
3.1.6.8 105000
-
-
 Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.1.6.8 cerebroside 3-sulfate + H2O Homo sapiens
-
 cerebroside + sulfate
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
3.1.6.8 Homo sapiens
-
-
-

Posttranslational Modification

EC Number Posttranslational Modification Comment Organism
3.1.6.8 glycoprotein 5-10% carbohydrate content Homo sapiens

Purification (Commentary)

EC Number Purification (Comment) Organism
3.1.6.8
-
 Homo sapiens

Reaction

EC Number Reaction Comment Organism Reaction ID
3.1.6.8 a cerebroside 3-sulfate + H2O = a cerebroside + sulfate hydrolyses galactose-3-sulfate residues in a number of lipids, also hydrolyses ascorbate 2-sulfate and many phenol sulfates, enzymes catalyze in addition to reaction of EC 3.1.6.8 also arylsulfatase reaction EC 3.1.6.1 Homo sapiens
a

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.1.6.8 liver
-
 Homo sapiens
-

Storage Stability

EC Number Storage Stability Organism
3.1.6.8 -20°C, protein: 1 mg/ml Homo sapiens

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.1.6.8 ascorbate 2-sulfate + H2O
-
 Homo sapiens ascorbate + sulfate
-
 ?
3.1.6.8 cerebroside 3-sulfate + H2O
-
 Homo sapiens cerebroside + sulfate
-
 ?
3.1.6.8 methylumbelliferyl sulfate + H2O
-
 Homo sapiens methylumbelliferone + sulfate
-
 ?
3.1.6.8 nitrocatechol sulfate + H2O
-
 Homo sapiens nitrocatechol + sulfate
-
 ?

Subunits

EC Number Subunits Comment Organism
3.1.6.8 dimer 1 * 49000, 1 * 55000, SDS-PAGE Homo sapiens
3.1.6.8 tetramer aggregation to tetramer at higher concentrations around pH 5, 2 * 49000, 2 * 55000 Homo sapiens

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
3.1.6.8 37
-
 assay Homo sapiens

Temperature Stability [°C]

EC Number Temperature Stability Minimum [°C] Temperature Stability Maximum [°C] Comment Organism
3.1.6.8 60
-
 t1/2: 7 min Homo sapiens