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Literature summary extracted from
- Purification and properties of human N-acetylgalactosamine-6-sulfate sulfatase (1981), Biochim. Biophys. Acta, 657, 344-355.
Inhibitors
| EC Number | Inhibitors | Comment | Organism | Structure |
|---|---|---|---|---|
| 3.1.6.4 | 6-Sulfated heptasaccharides | strong | Homo sapiens | |
| 3.1.6.4 | 6-Sulfated pentasaccharides | strong | Homo sapiens | |
| 3.1.6.4 | chondroitin 4-sulfate | slight | Homo sapiens |  |
| 3.1.6.4 | Chondroitin 6-sulfate tetrasaccharide | slight | Homo sapiens | |
| 3.1.6.4 | dermatan sulfate | slight | Homo sapiens | |
| 3.1.6.4 | heparin | slight | Homo sapiens | |
| 3.1.6.4 | hyaluronic acid | slight | Homo sapiens | |
KM Value [mM]
| EC Number | KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|---|
| 3.1.6.4 | 0.12 | - |
N-acetylgalactosamine 6-sulfate-beta(1-4)glucuronic acid-beta(1-3)-N-acetylgalactosaminitol 6-sulfate | - |
Homo sapiens | |
Molecular Weight [Da]
| EC Number | Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|---|
| 3.1.6.4 | 85000 | - |
x * 85000, SDS-PAGE | Homo sapiens |
| 3.1.6.4 | 90000 | - |
gel filtration | Homo sapiens |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 3.1.6.4 | Homo sapiens | - |
- |
- |
Purification (Commentary)
| EC Number | Purification (Comment) | Organism |
|---|---|---|
| 3.1.6.4 | - |
Homo sapiens |
Source Tissue
| EC Number | Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|---|
| 3.1.6.4 | placenta | - |
Homo sapiens | - |
| 3.1.6.4 | skin | fibroblast | Homo sapiens | - |
Specific Activity [micromol/min/mg]
| EC Number | Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|---|
| 3.1.6.4 | 0.000653 | - |
enzyme from fibroblasts | Homo sapiens |
| 3.1.6.4 | 0.00073 | - |
enzyme from placenta | Homo sapiens |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 3.1.6.4 | additional information | does not hydrolyze sulfate from N-acetylglucosamine 6-sulfate | Homo sapiens | ? | - |
? | |
| 3.1.6.4 | N-acetylgalactosamine 6-sulfate-beta(1-4)glucuronic acid-beta(1-3)-N-acetylgalactosaminitol 6-sulfate + H2O | sulfate is hydrolyzed only from the non-reducing terminal | Homo sapiens | sulfate + ? | - |
? | |
Subunits
| EC Number | Subunits | Comment | Organism |
|---|---|---|---|
| 3.1.6.4 | ? | x * 85000, SDS-PAGE | Homo sapiens |
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Release 2023.1 (January 2023)
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