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Literature summary extracted from

  • Purohit, A.; Potter, B.V.; Parker, M.G.; Reed, M.J.
    Steroid sulphatase: expression, isolation and inhibition for active-site identification studies (1998), Chem. Biol. Interact., 109, 183-193.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
3.1.6.2 expression in Escherichia coli and CHO cells Homo sapiens

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.1.6.2 estrone-3-O-sulfamate EMATE, most potent, irreversible; active site-directed inhibitor Helix pomatia
3.1.6.2 estrone-3-O-sulfamate EMATE, most potent, irreversible; active site-directed inhibitor Homo sapiens
3.1.6.2 Rose bengal histidine modification Helix pomatia

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.1.6.2 steroid sulfates + H2O Homo sapiens also acts on some related steryl sulfates, phenol sulfates, steroid arylsulfates and steroid alkyl sulfates catalyzed at the same site steroid + sulfate
-
 ?
3.1.6.2 steroid sulfates + H2O Helix pomatia also acts on some related steryl sulfates, phenol sulfates, steroid arylsulfates and steroid alkyl sulfates catalyzed at the same site steroid + sulfate
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
3.1.6.2 Helix pomatia
-
-
-
3.1.6.2 Homo sapiens
-
-
-

Posttranslational Modification

EC Number Posttranslational Modification Comment Organism
3.1.6.2 glycoprotein
-
 Homo sapiens
3.1.6.2 glycoprotein is glycosylated, binds to concanavalin A Helix pomatia

Purification (Commentary)

EC Number Purification (Comment) Organism
3.1.6.2 of the recombinant protein Homo sapiens
3.1.6.2 partial, the soluble enzyme Helix pomatia

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.1.6.2 placenta
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.1.6.2 dehydroepiandrosterone 3-sulfate + H2O
-
 Homo sapiens dehydroepiandrosterone + sulfate
-
 ?
3.1.6.2 dehydroepiandrosterone 3-sulfate + H2O
-
 Helix pomatia dehydroepiandrosterone + sulfate
-
 ?
3.1.6.2 estrone 3-sulfate + H2O
-
 Helix pomatia estrone + sulfate
-
 ?
3.1.6.2 estrone 3-sulfate + H2O
-
 Homo sapiens estrone + sulfate
-
 ?
3.1.6.2 steroid sulfates + H2O also acts on some related steryl sulfates, phenol sulfates, steroid arylsulfates and steroid alkyl sulfates catalyzed at the same site Homo sapiens steroid + sulfate
-
 ?
3.1.6.2 steroid sulfates + H2O also acts on some related steryl sulfates, phenol sulfates, steroid arylsulfates and steroid alkyl sulfates catalyzed at the same site Helix pomatia steroid + sulfate
-
 ?