Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary extracted from

  • Alperin, E.S.; Shapiro, L.J.
    Characterization of point mutations in patients with X-linked ichthyosis. Effects on the structure and function of the steroid sulfatase protein (1997), J. Biol. Chem., 272, 20756-20763.
    View publication on PubMed

Application

EC Number Application Comment Organism
3.1.6.2 medicine point mutations in 3 patients Homo sapiens
3.1.6.2 medicine deficiency in X-linked placental insufficiency and X-linked ichthyosis Homo sapiens

Cloned(Commentary)

EC Number Cloned (Comment) Organism
3.1.6.2 expression in mouse A9 cells Homo sapiens

Protein Variants

EC Number Protein Variants Comment Organism
3.1.6.2 C446Y patient with X-linked ichthyosis Homo sapiens
3.1.6.2 H444R patient with X-linked ichthyosis Homo sapiens
3.1.6.2 R419S patient with X-linked ichthyosis Homo sapiens
3.1.6.2 S341L patient with X-linked ichthyosis Homo sapiens
3.1.6.2 W372P patient with X-linked ichthyosis Homo sapiens
3.1.6.2 W372R patient with X-linked ichthyosis Homo sapiens

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
3.1.6.2 62000
-
 amino acid analysis Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.1.6.2 steroid sulfates + H2O Homo sapiens also acts on some related steryl sulfates, phenol sulfates, steroid arylsulfates and steroid alkyl sulfates catalyzed at the same site steroid + sulfate
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
3.1.6.2 Homo sapiens
-
-
-

Posttranslational Modification

EC Number Posttranslational Modification Comment Organism
3.1.6.2 glycoprotein 4 sites for possible glycosylation, only 2 sites used Homo sapiens

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.1.6.2 estrone sulfate + H2O
-
 Homo sapiens estrone + sulfate
-
 ?
3.1.6.2 steroid sulfates + H2O also acts on some related steryl sulfates, phenol sulfates, steroid arylsulfates and steroid alkyl sulfates catalyzed at the same site Homo sapiens steroid + sulfate
-
 ?