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Literature summary extracted from
- Human liver N-acetylglucosamine-6-sulphate sulphatase. Catalytic properties (1987), Biochem. J., 246, 355-365.
Activating Compound
| EC Number | Activating Compound | Comment | Organism | Structure |
|---|---|---|---|---|
| 3.1.6.14 | dithiothreitol | maximum activity at 0.1 mM | Homo sapiens |  |
General Stability
| EC Number | General Stability | Organism |
|---|---|---|
| 3.1.6.14 | bovine serum albumin stabilizes | Homo sapiens |
Inhibitors
| EC Number | Inhibitors | Comment | Organism | Structure |
|---|---|---|---|---|
| 3.1.6.14 | bovine serum albumin | - |
Homo sapiens | |
| 3.1.6.14 | PO43- | - |
Bos taurus | |
| 3.1.6.14 | PO43- | - |
Homo sapiens | |
| 3.1.6.14 | SO42- | - |
Bos taurus | |
| 3.1.6.14 | SO42- | - |
Homo sapiens | |
KM Value [mM]
| EC Number | KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|---|
| 3.1.6.14 | 0.0035 | - |
O-(alpha-glucosamine 6-sulfate)-(1-4)-L-O-(alpha-iduronic acid 2-sulfate)-(1-4)-D-O-2,5-anhydro mannitol 6-sulfate | - |
Homo sapiens | |
| 3.1.6.14 | 0.0071 | - |
N-acetylglucosamine 6-sulfate | - |
Homo sapiens | |
| 3.1.6.14 | 0.0108 | - |
O-(alpha-2-sulfamino glucosamine 6-sulfate)-(1-4)-L-idose | - |
Homo sapiens | |
| 3.1.6.14 | 0.062 | - |
glucose 6-sulfate | form A and B | Homo sapiens | |
Molecular Weight [Da]
| EC Number | Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|---|
| 3.1.6.14 | 70000 | - |
- |
Rattus norvegicus |
Natural Substrates/ Products (Substrates)
| EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 3.1.6.14 | N-acetyl-D-glucosamine 6-sulfate units + H2O | Bos taurus | - |
N-acetyl-D-glucosamine units + sulfate | - |
? | |
| 3.1.6.14 | N-acetyl-D-glucosamine 6-sulfate units + H2O | Homo sapiens | in oligo-and monosaccharides derived from heparan sulfate and keratan sulfate | N-acetyl-D-glucosamine units + sulfate | - |
? | |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 3.1.6.14 | Bos taurus | - |
- |
- |
| 3.1.6.14 | Homo sapiens | - |
- |
- |
| 3.1.6.14 | Rattus norvegicus | - |
- |
- |
Source Tissue
| EC Number | Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|---|
| 3.1.6.14 | kidney | - |
Homo sapiens | - |
| 3.1.6.14 | kidney | - |
Bos taurus | - |
| 3.1.6.14 | liver | - |
Homo sapiens | - |
| 3.1.6.14 | skin fibroblast | in culture | Homo sapiens | - |
| 3.1.6.14 | skin fibroblast | in culture | Rattus norvegicus | - |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 3.1.6.14 | glucose 6-sulfate + H2O | - |
Homo sapiens | glucose + sulfate | - |
? | |
| 3.1.6.14 | N-acetyl-D-glucosamine 6-sulfate + H2O | - |
Homo sapiens | N-acetyl-D-glucosamine + sulfate | - |
? | |
| 3.1.6.14 | N-acetyl-D-glucosamine 6-sulfate units + H2O | - |
Bos taurus | N-acetyl-D-glucosamine units + sulfate | - |
? | |
| 3.1.6.14 | N-acetyl-D-glucosamine 6-sulfate units + H2O | in substrates bearing a N-acetylglucosamine 6-sulfate residue at its nonreducing terminus derived from heparan sulfate and keratan sulfate | Homo sapiens | N-acetyl-D-glucosamine units + sulfate | - |
? | |
| 3.1.6.14 | N-acetyl-D-glucosamine 6-sulfate units + H2O | specific exosulfatase for desulfation of the nonreducing terminal N-acetylglucosamine 6-sulfate residues of heparansulfate | Homo sapiens | N-acetyl-D-glucosamine units + sulfate | - |
? | |
| 3.1.6.14 | N-acetyl-D-glucosamine 6-sulfate units + H2O | in oligo-and monosaccharides derived from heparan sulfate and keratan sulfate | Homo sapiens | N-acetyl-D-glucosamine units + sulfate | - |
? | |
| 3.1.6.14 | O-(alpha-2-sulfamino glucosamine 6-sulfate)-(1-4)-L-idonic acid + H2O | - |
Homo sapiens | O-(alpha-2-sulfamino glucosamine)-(1-4)-L-idose + sulfate | - |
? | |
| 3.1.6.14 | O-(alpha-2-sulfamino glucosamine 6-sulfate)-(1-4)-L-idose + H2O | - |
Homo sapiens | O-(alpha-2-sulfamino glucosamine)-(1-4)-L-idose + sulfate | - |
? | |
| 3.1.6.14 | O-(alpha-glucosamine 6-sulfate)-(1-4)-L-O-(alpha-iduronic acid 2-sulfate)-(1-4)-D-O-2,5-anhydro mannitol 6-sulfate + H2O | - |
Homo sapiens | O-(alpha-glucosamine)-(1-4)-L-O-(alpha-iduronic acid 2-sulfate)-(1-4)-D-O-2,5-anhydro mannitol 6-sulfate + sulfate | - |
? | |
pH Optimum
| EC Number | pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|---|
| 3.1.6.14 | 4.2 | 6 | depending on substrate structure, overview | Homo sapiens |
| 3.1.6.14 | 4.3 | - |
O-(alpha-glucosamine 6-sulfate)-(1-4)-L-O-(alpha-iduronic acid 2-sulfate)-(1-4)-D-O-2,5-anhydro mannitol 6-sulfate | Homo sapiens |
| 3.1.6.14 | 4.8 | - |
O-(alpha-2-sulfamino glucosamine 6-sulfate)-(1-4)-L-idose | Homo sapiens |
| 3.1.6.14 | 5.7 | - |
glucose 6-sulfate, N-acetylglucosamine 6-sulfate | Homo sapiens |
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