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Literature summary extracted from

  • Lissens, W.; Zenati, A.; Liebaers, I.
    Polyclonal antibodies against iduronate 2-sulphate sulphatase from human urine (1984), Biochim. Biophys. Acta, 801, 365-371.
    View publication on PubMed

General Stability

EC Number General Stability Organism
3.1.6.13 in water rapid loss of activity Homo sapiens

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.1.6.13 chondroitin 4-sulfate at 0.1 mM Homo sapiens
3.1.6.13 chondroitin 6-sulfate at 0.1 mM Homo sapiens
3.1.6.13 Cl-
-
 Homo sapiens
3.1.6.13 heparan sulfate
-
 Homo sapiens
3.1.6.13 NaCl due to Cl- Homo sapiens
3.1.6.13 phosphate
-
 Homo sapiens
3.1.6.13 SO42- organic sulfates Homo sapiens

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
3.1.6.13 0.0115
-
 O-(alpha-L-idopyranosyluronic acid 2-sulfate)-(1-4)-2,5-anhydro-D-mannitol 6-sulfate pool 1 from urine Homo sapiens
3.1.6.13 0.013
-
 O-(alpha-L-idopyranosyluronic acid 2-sulfate)-(1-4)-2,5-anhydro-D-mannitol 6-sulfate pool 2 in urine Homo sapiens

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
3.1.6.13 lysosome
-
 Homo sapiens 5764
-

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
3.1.6.13 95000
-
-
 Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.1.6.13 dermatan sulfate + H2O Homo sapiens
-
 dermatan + sulfate
-
 ?
3.1.6.13 heparan sulfate + H2O Homo sapiens
-
 dermatan + sulfate
-
 ?
3.1.6.13 heparin + H2O Homo sapiens
-
 desulfated heparin + sulfate
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
3.1.6.13 Homo sapiens
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
3.1.6.13
-
 Homo sapiens

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.1.6.13 urine
-
 Homo sapiens
-

Storage Stability

EC Number Storage Stability Organism
3.1.6.13 -20°C, neutral pH, for one year or more Homo sapiens
3.1.6.13 4°C, pH 7.2, 150 mM NaCl, several days Homo sapiens

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.1.6.13 dermatan sulfate + H2O
-
 Homo sapiens dermatan + sulfate
-
 ?
3.1.6.13 heparan sulfate + H2O
-
 Homo sapiens dermatan + sulfate
-
 ?
3.1.6.13 heparin + H2O
-
 Homo sapiens desulfated heparin + sulfate
-
 ?
3.1.6.13 O-(alpha-L-idopyranosyluronic acid 2-sulfate)-(1-4)-2,5-anhydro-D-mannitol 6-sulfate + H2O
-
 Homo sapiens O-(alpha-L-idopyranosyluronic acid)-(1-4)-2,5-anhydro-D-mannitol 6-sulfate + sulfate
-
 ?

Temperature Stability [°C]

EC Number Temperature Stability Minimum [°C] Temperature Stability Maximum [°C] Comment Organism
3.1.6.13 50
-
 stable for 10 min Homo sapiens
3.1.6.13 75
-
 2 min, complete loss of activity Homo sapiens