Literature summary extracted from

Kim, J.H.; Suh, Y.J.; Lee, T.G.; Kim, Y.; Bae, S.S.; Kim, M.J.; Lambeth, J.D.; Suh, P.G.; Ryu, S.H.
Inhibition of phospholipase D by a protein factor from bovine brain cytosol. Partial purification and characterization of the inhibition mechanism (1996), J. Biol. Chem., 271, 25213-25219.

Activating Compound

EC Number	Activating Compound	Comment	Organism	Structure
3.1.4.4	ADP-ribosylation factor	GTP dependent activation	Bos taurus
3.1.4.4	phosphatidylinositol 4,5-bisphosphate	essential cofactor	Bos taurus

Inhibitors

EC Number	Inhibitors	Comment	Organism	Structure
3.1.4.4	30kDA protein factor from bovine brain cytosol	inhibition due to interaction with phosphatidylinositol 4,5-biphosphate	Bos taurus

Localization

EC Number	Localization	Comment	Organism	GeneOntology No.	Textmining

Natural Substrates/ Products (Substrates)

EC Number	Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
3.1.4.4	phospholipid + H2O	Bos taurus	phosphoric ester hydrolysis	phosphatidic acid + alcohol	-	?

Organism

EC Number	Organism	UniProt	Comment	Textmining
3.1.4.4	Bos taurus	-	-	-

Source Tissue

EC Number	Source Tissue	Comment	Organism	Textmining
3.1.4.4	brain	-	Bos taurus	-

Substrates and Products (Substrate)

EC Number	Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
3.1.4.4	phospholipid + H2O	phosphoric ester hydrolysis	Bos taurus	phosphatidic acid + alcohol	-	?

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Release 2023.1 (January 2023)