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Literature summary extracted from

  • Giorgi, M.; Caniglia, C.; Scarsella, G.; Augusti-Tocco, G.
    Characterization of 3':5' cyclic nucleotide phosphodiesterase activities of mouse neuroblastoma N18TG2 cells (1993), FEBS Lett., 324, 76-80.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
3.1.4.35 Triton X-100
-
 Mus musculus

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.1.4.17 5-(2-propoxyphenyl)-2,3-dihydro-7H-[1,2,3]triazolo[4,5-d]pyrimidin-7-one
-
 Mus musculus
3.1.4.35 5-(2-propoxyphenyl)-2,3-dihydro-7H-[1,2,3]triazolo[4,5-d]pyrimidin-7-one
-
 Mus musculus
3.1.4.35 zaprinast
-
 Mus musculus
3.1.4.53 RO 201724
-
 Mus musculus
3.1.4.53 rolipram
-
 Mus musculus

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
3.1.4.17 additional information
-
 additional information biphasic behaviour with 3',5'-cAMP as substrate Mus musculus
3.1.4.17 0.0088
-
 3',5'-cGMP
-
 Mus musculus
3.1.4.35 0.0047
-
 3',5'-cGMP
-
 Mus musculus
3.1.4.53 0.0032
-
 3',5'-cAMP
-
 Mus musculus

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
3.1.4.35 182000
-
 gel filtration Mus musculus
3.1.4.35 182000
-
 gel filtration, sucrose density gradient centrifugation Mus musculus
3.1.4.53 56000
-
 gel filtration, sucrose density gradient centrifugation Mus musculus

Organism

EC Number Organism UniProt Comment Textmining
3.1.4.17 Mus musculus
-
-
-
3.1.4.35 Mus musculus
-
-
-
3.1.4.53 Mus musculus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.1.4.17 N18TG2 cell
-
 Mus musculus
-
3.1.4.35 N18TG2 cell
-
 Mus musculus
-
3.1.4.53 N18TG2 cell
-
 Mus musculus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.1.4.17 3',5'-cAMP + H2O
-
 Mus musculus 5'-AMP
-
 ?
3.1.4.17 3',5'-cGMP + H2O
-
 Mus musculus 5'-GMP
-
 ?
3.1.4.53 3',5'-cAMP + H2O
-
 Mus musculus 5'-AMP
-
 ?

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
3.1.4.17 0.0003
-
 5-(2-propoxyphenyl)-2,3-dihydro-7H-[1,2,3]triazolo[4,5-d]pyrimidin-7-one
-
 Mus musculus
3.1.4.35 0.0012
-
 5-(2-propoxyphenyl)-2,3-dihydro-7H-[1,2,3]triazolo[4,5-d]pyrimidin-7-one
-
 Mus musculus
3.1.4.53 0.002
-
 rolipram
-
 Mus musculus
3.1.4.53 0.0076
-
 RO 201724
-
 Mus musculus