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Literature summary extracted from
- Purification and properties of 3',5'-cyclic nucleotide phosphodiesterase from dog heart (1966), Biochemistry, 5, 150-157.
Activating Compound
| EC Number | Activating Compound | Comment | Organism | Structure |
|---|---|---|---|---|
| 3.1.4.17 | imidazole | - |
Canis lupus familiaris |  |
| 3.1.4.17 | NH4+ | stimulates | Canis lupus familiaris | |
Inhibitors
| EC Number | Inhibitors | Comment | Organism | Structure |
|---|---|---|---|---|
| 3.1.4.17 | Caffeine | noncompetitive, dog heart | Canis lupus familiaris | |
| 3.1.4.17 | Co2+ | inhibits at higher concentrations | Canis lupus familiaris | |
| 3.1.4.17 | Mg2+ | inhibits at higher amounts | Canis lupus familiaris | |
KM Value [mM]
| EC Number | KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|---|
| 3.1.4.17 | additional information | - |
additional information | - |
Canis lupus familiaris |
Metals/Ions
| EC Number | Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|---|
| 3.1.4.17 | Co2+ | can substitute for Mg2+ | Canis lupus familiaris | |
| 3.1.4.17 | Mg2+ | dependent on | Canis lupus familiaris | |
| 3.1.4.17 | Mn2+ | can substitute for Mg2+ | Canis lupus familiaris | |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 3.1.4.17 | Canis lupus familiaris | - |
- |
- |
Purification (Commentary)
| EC Number | Purification (Comment) | Organism |
|---|---|---|
| 3.1.4.17 | 173fold | Canis lupus familiaris |
Source Tissue
| EC Number | Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|---|
| 3.1.4.17 | heart | - |
Canis lupus familiaris | - |
Specific Activity [micromol/min/mg]
| EC Number | Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|---|
| 3.1.4.17 | additional information | - |
- |
Canis lupus familiaris |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 3.1.4.17 | 3',5'-cCMP + H2O | - |
Canis lupus familiaris | 5'-CMP | - |
? | |
| 3.1.4.17 | 3',5'-cdAMP + H2O | - |
Canis lupus familiaris | 5'-dAMP | - |
? | |
| 3.1.4.17 | nucleoside 3',5'-cyclic phosphate + H2O | - |
Canis lupus familiaris | nucleoside 5'-phosphate | - |
? | |
pH Optimum
| EC Number | pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|---|
| 3.1.4.17 | 8.5 | 9.2 | - |
Canis lupus familiaris |
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Release 2023.1 (January 2023)
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