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Literature summary extracted from

  • Ryan, J.A.; Toscano, W.A.
    Multiple forms of cyclic nucleotide phosphodiesterase in a murine adrenal cortex cell line (Y-1) (1985), Arch. Biochem. Biophys., 241, 403-412.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.1.4.17 Calmidazolium soluble but not particulate form Mus musculus
3.1.4.17 cAMP particulate enzyme Mus musculus
3.1.4.17 Chloropromazine soluble but not particulate form Mus musculus
3.1.4.17 ethylene glycol bis(beta-aminoethyl ether)-N,N'-tetraacetic acid soluble but not particulate form Mus musculus
3.1.4.17 N-(6-Aminohexyl)-5-chloro-1-naphthalenesulfonamide soluble but not particulate form Mus musculus

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
3.1.4.17 0.03
-
 3',5'-cGMP soluble enzyme Mus musculus
3.1.4.17 0.09
-
 3',5'-cAMP particulate enzyme Mus musculus
3.1.4.17 0.1
-
 3',5'-cGMP particulate enzyme Mus musculus
3.1.4.17 0.125
-
 3',5'-cAMP soluble enzyme Mus musculus

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
3.1.4.17 Ca2+ Ca2+/calmodulin stimulated Mus musculus

Organism

EC Number Organism UniProt Comment Textmining
3.1.4.17 Mus musculus
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
3.1.4.17 540fold Mus musculus

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.1.4.17 Y-1 cell
-
 Mus musculus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.1.4.17 3',5'-cAMP + H2O
-
 Mus musculus 5'-AMP
-
 ?
3.1.4.17 3',5'-cGMP + H2O
-
 Mus musculus 5'-GMP
-
 ?
3.1.4.17 nucleoside 3',5'-cyclic phosphate + H2O
-
 Mus musculus nucleoside 5'-phosphate
-
 ?