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Literature summary extracted from
- Characteristics and partial purification of a novel cytosolic, magnesium-independent, neutral sphingomyelinase activated in the early signal transduction of 1alpha,25-dihydroxyvitamin D3-induced HL-60 cell differentiation (1994), J. Biol. Chem., 269, 4070-4077.
Activating Compound
| EC Number | Activating Compound | Comment | Organism | Structure |
|---|---|---|---|---|
| 3.1.4.12 | deoxycholate | - |
Homo sapiens |  |
| 3.1.4.12 | additional information | - |
Homo sapiens | |
| 3.1.4.12 | phosphatidic acid | - |
Homo sapiens | |
| 3.1.4.12 | phosphatidylinositol | - |
Homo sapiens | |
| 3.1.4.12 | phosphatidylserine | - |
Homo sapiens | |
Inhibitors
| EC Number | Inhibitors | Comment | Organism | Structure |
|---|---|---|---|---|
| 3.1.4.12 | Ca2+ | slight | Homo sapiens | |
| 3.1.4.12 | Cu2+ | - |
Homo sapiens | |
| 3.1.4.12 | Fe3+ | - |
Homo sapiens | |
| 3.1.4.12 | additional information | - |
Homo sapiens | |
| 3.1.4.12 | Zn2+ | - |
Homo sapiens | |
Localization
| EC Number | Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|---|
| 3.1.4.12 | cytosol | - |
Homo sapiens | 5829 | - |
Molecular Weight [Da]
| EC Number | Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|---|
| 3.1.4.12 | 45000 | - |
1 * 95000 + 1 * 45000, gel filtration | Homo sapiens |
| 3.1.4.12 | 95000 | - |
1 * 95000 + 1 * 45000, gel filtration | Homo sapiens |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 3.1.4.12 | Homo sapiens | - |
- |
- |
Purification (Commentary)
| EC Number | Purification (Comment) | Organism |
|---|---|---|
| 3.1.4.12 | 4475fold | Homo sapiens |
Source Tissue
| EC Number | Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|---|
| 3.1.4.12 | HL-60 cell | - |
Homo sapiens | - |
Specific Activity [micromol/min/mg]
| EC Number | Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|---|
| 3.1.4.12 | additional information | - |
different assay conditions, substrates etc. | Homo sapiens |
Subunits
| EC Number | Subunits | Comment | Organism |
|---|---|---|---|
| 3.1.4.12 | dimer | 1 * 95000 + 1 * 45000, gel filtration | Homo sapiens |
pH Optimum
| EC Number | pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|---|
| 3.1.4.12 | 7.5 | - |
- |
Homo sapiens |
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