Literature summary extracted from

Gehm, B.D.; Pinke, R.M.; Laquerre, S.; Chafouleas, J.G.; Schultz, D.A.; Pepperl, D.J.; McConnell, D.G.
Activation of bovine rod outer segment phosphatidylinositol-4,5-bisphosphate phospholipase C by calmodulin antagonists does not depend on calmodulin (1991), Biochemistry, 30, 11302-11306.

Activating Compound

EC Number	Activating Compound	Comment	Organism	Structure
3.1.4.11	(2-{4-methoxy-3,5-bis-[2-methoxy-5-(2-methylamino-ethyl)-benzyl]-phenyl}-ethyl)-methyl amine	compound 48/80 i.e. (2-{4-methoxy-3,5-bis-[2-methoxy-5-(2-methylamino-ethyl)-benzyl]-phenyl}-ethyl)-methyl amine, CAS REG. NO.: 94724-12-6, the calmodulin antagonists activate at least one form of the rod outer segment enzyme by a calmodulin-independent mechanism	Bos taurus
3.1.4.11	Calmidazolium	the calmodulin antagonists activate at least one form of the rod outer segment enzyme by a calmodulin-independent mechanism	Bos taurus
3.1.4.11	Calmodulin antagonists	activate at least one form of the rod outer segment enzyme by a calmodulin-independent mechanism	Bos taurus
3.1.4.11	Melittin	the calmodulin antagonists activate at least one form of the rod outer segment enzyme by a calmodulin-independent mechanism	Bos taurus
3.1.4.11	N-(4-aminobutyl)-5-chloro-1-naphthalenesulfonamide	the calmodulin antagonists activate at least one form of the rod outer segment enzyme by a calmodulin-independent mechanism	Bos taurus
3.1.4.11	N-(6-Aminohexyl)-5-chloro-1-naphthalenesulfonamide	the calmodulin antagonists activate at least one form of the rod outer segment enzyme by a calmodulin-independent mechanism	Bos taurus
3.1.4.11	Trifluoperazine	the calmodulin antagonists activate at least one form of the rod outer segment enzyme by a calmodulin-independent mechanism	Bos taurus

Localization

EC Number	Localization	Comment	Organism	GeneOntology No.	Textmining
3.1.4.11	photoreceptor outer segment	rod outer segment	Bos taurus	1750	-

Organism

EC Number	Organism	UniProt	Comment	Textmining
3.1.4.11	Bos taurus	-	-	-

Substrates and Products (Substrate)

EC Number	Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
3.1.4.11	phosphatidylinositol 4,5-bisphosphate + H2O	-	Bos taurus	D-myo-inositol 1,4,5-trisphosphate + diacylglycerol	-	?

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Release 2023.1 (January 2023)