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Literature summary extracted from

  • Banno, Y.; Nozawa, Y.
    Characterization of partially purified phospholipase C from human platelet membranes (1987), Biochem. J., 248, 95-101.
    View publication on PubMedView publication on EuropePMC

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
3.1.4.11 cytosol
-
 Homo sapiens 5829
-
3.1.4.11 membrane
-
 Homo sapiens 16020
-

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
3.1.4.11 Ca2+ required, maximal hydrolysis of phosphatidylinositol 4,5-diphosphate at 0.004 mM, maximal hydrolysis of phosphatidylinositol at 0.5 mM Homo sapiens

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
3.1.4.11 110000
-
 gel filtration Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.1.4.11 additional information Homo sapiens plays a critical role in signal transduction in the receptor-activated human platelets ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
3.1.4.11 Homo sapiens
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
3.1.4.11 enzyme from platelet membrane Homo sapiens

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.1.4.11 platelet
-
 Homo sapiens
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
3.1.4.11 0.5784
-
-
 Homo sapiens

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.1.4.11 additional information plays a critical role in signal transduction in the receptor-activated human platelets Homo sapiens ?
-
 ?
3.1.4.11 phosphatidylinositol + H2O
-
 Homo sapiens ?
-
 ?
3.1.4.11 phosphatidylinositol 4,5-bisphosphate + H2O preferentially hydrolyzed Homo sapiens D-myo-inositol 1,4,5-trisphosphate + diacylglycerol
-
 ?

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
3.1.4.11 6.5
-
 hydrolysis of phosphatidylinositol 4,5-bisphosphate, in presence of sodium deoxycholate, enzyme from plasma membrane Homo sapiens
3.1.4.11 7.3
-
 hydrolysis of phosphatidylinositol 4,5-bisphosphate, in presence of sodium deoxycholate, enzyme from cytoplasm Homo sapiens