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Literature summary extracted from

  • English, D.; Martin, M.; Harvea, K.A.; Akard, L.P.; Allen, R.; Widlanski, T.S.; Garcia, J.G.; Siddiqui, R.A.
    Characterization and purification of neutrophil ecto-phosphatidic acid phosphohydrolase (1997), Biochem. J., 324, 941-950.
No PubMed abstract available

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.1.3.4 dihydrosphingosine
-
 Homo sapiens
3.1.3.4 dimethylsphingosine
-
 Homo sapiens
3.1.3.4 F- NaF Homo sapiens
3.1.3.4 Mg2+ MgCl2 Homo sapiens
3.1.3.4 NEM no inhibition Homo sapiens
3.1.3.4 phosphatidic acid competitive inhibition Homo sapiens
3.1.3.4 propanolol
-
 Homo sapiens
3.1.3.4 sphingosine
-
 Homo sapiens

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
3.1.3.4 1.4
-
 dioctanoyl phosphatidic acid
-
 Homo sapiens

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
3.1.3.4 plasma membrane
-
 Homo sapiens 5886
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.1.3.4 additional information Homo sapiens the enzyme may play an important role in regulating inflammatory cell responses to extracellular phosphatidic acid in biological system ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
3.1.3.4 Homo sapiens
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
3.1.3.4
-
 Homo sapiens

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.1.3.4 neutrophil
-
 Homo sapiens
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
3.1.3.4 0.1175
-
-
 Homo sapiens

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.1.3.4 didecanoyl phosphatidic acid + H2O
-
 Homo sapiens 1,2-didecanoyl-sn-glycerol + phosphate
-
 ?
3.1.3.4 dihexanoyl phosphatidic acid + H2O
-
 Homo sapiens 1,2-dihexanoyl-sn-glycerol + phosphate
-
 ?
3.1.3.4 dimyristoyl phosphatidic acid + H2O
-
 Homo sapiens 1,2-dimyristoyl-sn-glycerol + phosphate
-
 ?
3.1.3.4 dioctanoyl phosphatidic acid + H2O
-
 Homo sapiens 1,2-dioctanoyl-sn-glycerol + phosphate
-
 ?
3.1.3.4 dioleoyl phosphatidic acid + H2O
-
 Homo sapiens 1,2-dioleoyl-sn-glycerol + phosphate
-
 ?
3.1.3.4 dipalmitoyl phosphatidic acid + H2O
-
 Homo sapiens ?
-
 ?
3.1.3.4 lysophosphatidate + H2O
-
 Homo sapiens ?
-
 ?
3.1.3.4 additional information both long and short chain lysophosphatidic acids are hydrolyzed at rates comparable with that observed for short chain phosphatidic acids Homo sapiens ?
-
 ?
3.1.3.4 additional information the enzyme may play an important role in regulating inflammatory cell responses to extracellular phosphatidic acid in biological system Homo sapiens ?
-
 ?
3.1.3.4 octanoyl lysophosphatidic acid + H2O
-
 Homo sapiens ?
-
 ?
3.1.3.4 oleoyl phosphatidic acid + H2O
-
 Homo sapiens ?
-
 ?
3.1.3.4 phosphatidic acid + H2O
-
 Homo sapiens 1,2-diacyl-sn-glycerol + phosphate
-
 ?

Subunits

EC Number Subunits Comment Organism
3.1.3.4 ? x * 45000-52000, SDS-PAGE Homo sapiens