BRENDA - Enzyme Database

Plasma membrane form of phosphatidate phosphohydrolase: a possible role in signal transduction during liver fibrogenesis

Day, C.P.; Burt, A.D.; Brown, A.S.M.; Bennett, M.K.; Farrell, D.J.; James, O.F.W.; Yeaman, S.J.; Clin. Sci. 85, 281-287 (1993)

Data extracted from this reference:

Inhibitors
EC Number
Inhibitors
Commentary
Organism
Structure
3.1.3.4
NEM
the enzyme from plasma membrane is insensitive to inhibition, the enzyme from cytosol and microsomes is sensitive to NEM
Homo sapiens
Localization
EC Number
Localization
Commentary
Organism
GeneOntology No.
Textmining
3.1.3.4
cytosol
-
Homo sapiens
5829
-
3.1.3.4
microsome
-
Homo sapiens
-
-
3.1.3.4
plasma membrane
-
Homo sapiens
5886
-
Natural Substrates/ Products (Substrates)
EC Number
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
3.1.3.4
additional information
Homo sapiens
the enzyme from plasma membrane increases in liver fibrosis but not regeneration. Stimulation of phosphatidate phosphohydrolase with its effect on the diacylglycerol/phosphatidate ratio may play a role in transduction of the fibrosis signal
?
-
-
-
Organism
EC Number
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
3.1.3.4
Homo sapiens
-
-
-
Substrates and Products (Substrate)
EC Number
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
3.1.3.4
additional information
the enzyme from plasma membrane increases in liver fibrosis but not regeneration. Stimulation of phosphatidate phosphohydrolase with its effect on the diacylglycerol/phosphatidate ratio may play a role in transduction of the fibrosis signal
134889
Homo sapiens
?
-
-
-
-
3.1.3.4
phosphatidic acid + H2O
-
134889
Homo sapiens
1,2-diacyl-sn-glycerol + phosphate
-
-
-
?
Inhibitors (protein specific)
EC Number
Inhibitors
Commentary
Organism
Structure
3.1.3.4
NEM
the enzyme from plasma membrane is insensitive to inhibition, the enzyme from cytosol and microsomes is sensitive to NEM
Homo sapiens
Localization (protein specific)
EC Number
Localization
Commentary
Organism
GeneOntology No.
Textmining
3.1.3.4
cytosol
-
Homo sapiens
5829
-
3.1.3.4
microsome
-
Homo sapiens
-
-
3.1.3.4
plasma membrane
-
Homo sapiens
5886
-
Natural Substrates/ Products (Substrates) (protein specific)
EC Number
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
3.1.3.4
additional information
Homo sapiens
the enzyme from plasma membrane increases in liver fibrosis but not regeneration. Stimulation of phosphatidate phosphohydrolase with its effect on the diacylglycerol/phosphatidate ratio may play a role in transduction of the fibrosis signal
?
-
-
-
Substrates and Products (Substrate) (protein specific)
EC Number
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
3.1.3.4
additional information
the enzyme from plasma membrane increases in liver fibrosis but not regeneration. Stimulation of phosphatidate phosphohydrolase with its effect on the diacylglycerol/phosphatidate ratio may play a role in transduction of the fibrosis signal
134889
Homo sapiens
?
-
-
-
-
3.1.3.4
phosphatidic acid + H2O
-
134889
Homo sapiens
1,2-diacyl-sn-glycerol + phosphate
-
-
-
?