BRENDA - Enzyme Database

Properties of phosphatidate phosphohydrolase in rat adipose tissue

Jamdar, S.C.; Cao, W.F.; Biochem. J. 301, 793-799 (1994)

Data extracted from this reference:

Inhibitors
EC Number
Inhibitors
Commentary
Organism
Structure
3.1.3.4
2,2'-dithiodipyridine
9 mM, 90% inhibition of Mg2+-dependent enzyme, 16% inhibition of Mg2+-independent enzyme
Rattus norvegicus
3.1.3.4
4,4'-dithiodipyridine
9.0 mM, 96% inhibition of Mg2+-dependent enzyme, 20% inhibition of Mg2+-independent enzyme
Rattus norvegicus
3.1.3.4
5,5'-dithiobis(2-nitrobenzoic acid)
0.2 mM, 80% inhibition of Mg2+-dependent enzyme, no inhibition of Mg2+-independent enzyme
Rattus norvegicus
3.1.3.4
cystamine dihydrochloride
1 mM, 25% inhibition of Mg2+-dependent enzyme, 8% inhibition of Mg2+-independent enzyme
Rattus norvegicus
3.1.3.4
N,N'-p-phenylenedimaleimide
0.4 mM, 44% inhibition of Mg2+-dependent enzyme, 7% inhibition of Mg2+-independent enzyme
Rattus norvegicus
3.1.3.4
NEM
1 mM, 80% inhibition of Mg2+-dependent enzyme, 10% inhibition of Mg2+-independent enzyme
Rattus norvegicus
3.1.3.4
thimerosal
0.5 mM, 85% inhibition of Mg2+-dependent enzyme, 12% inhibition of Mg2+-independent enzyme
Rattus norvegicus
Localization
EC Number
Localization
Commentary
Organism
GeneOntology No.
Textmining
3.1.3.4
cytosol
Mg2+-dependent enzyme form is mainly located in cytosol and microsomes
Rattus norvegicus
5829
-
3.1.3.4
microsome
Mg2+-dependent enzyme form is mainly located in cytosol and microsomes. The Mg2+-independent enzyme is mainly located in plasma membrane, mitochondria and microsomes
Rattus norvegicus
-
-
3.1.3.4
mitochondrion
the Mg2+-independent enzyme is mainly located in plasma membrane, mitochondria and microsomes
Rattus norvegicus
5739
-
3.1.3.4
plasma membrane
the Mg2+-independent enzyme is mainly located in plasma membrane, mitochondria and microsomes
Rattus norvegicus
5886
-
Metals/Ions
EC Number
Metals/Ions
Commentary
Organism
Structure
3.1.3.4
Mg2+
adipose tissue contains 2 different enzyme forms: a Mg2+-dependent form and a Mg2+-independent form
Rattus norvegicus
Natural Substrates/ Products (Substrates)
EC Number
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
3.1.3.4
additional information
Rattus norvegicus
-
?
-
-
-
Organism
EC Number
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
3.1.3.4
Rattus norvegicus
-
-
-
Source Tissue
EC Number
Source Tissue
Commentary
Organism
Textmining
3.1.3.4
adipose tissue
-
Rattus norvegicus
-
Substrates and Products (Substrate)
EC Number
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
3.1.3.4
additional information
-
134882
Rattus norvegicus
?
-
-
-
-
3.1.3.4
phosphatidic acid + H2O
-
134882
Rattus norvegicus
1,2-diacyl-sn-glycerol + phosphate
-
-
-
?
Inhibitors (protein specific)
EC Number
Inhibitors
Commentary
Organism
Structure
3.1.3.4
2,2'-dithiodipyridine
9 mM, 90% inhibition of Mg2+-dependent enzyme, 16% inhibition of Mg2+-independent enzyme
Rattus norvegicus
3.1.3.4
4,4'-dithiodipyridine
9.0 mM, 96% inhibition of Mg2+-dependent enzyme, 20% inhibition of Mg2+-independent enzyme
Rattus norvegicus
3.1.3.4
5,5'-dithiobis(2-nitrobenzoic acid)
0.2 mM, 80% inhibition of Mg2+-dependent enzyme, no inhibition of Mg2+-independent enzyme
Rattus norvegicus
3.1.3.4
cystamine dihydrochloride
1 mM, 25% inhibition of Mg2+-dependent enzyme, 8% inhibition of Mg2+-independent enzyme
Rattus norvegicus
3.1.3.4
N,N'-p-phenylenedimaleimide
0.4 mM, 44% inhibition of Mg2+-dependent enzyme, 7% inhibition of Mg2+-independent enzyme
Rattus norvegicus
3.1.3.4
NEM
1 mM, 80% inhibition of Mg2+-dependent enzyme, 10% inhibition of Mg2+-independent enzyme
Rattus norvegicus
3.1.3.4
thimerosal
0.5 mM, 85% inhibition of Mg2+-dependent enzyme, 12% inhibition of Mg2+-independent enzyme
Rattus norvegicus
Localization (protein specific)
EC Number
Localization
Commentary
Organism
GeneOntology No.
Textmining
3.1.3.4
cytosol
Mg2+-dependent enzyme form is mainly located in cytosol and microsomes
Rattus norvegicus
5829
-
3.1.3.4
microsome
Mg2+-dependent enzyme form is mainly located in cytosol and microsomes. The Mg2+-independent enzyme is mainly located in plasma membrane, mitochondria and microsomes
Rattus norvegicus
-
-
3.1.3.4
mitochondrion
the Mg2+-independent enzyme is mainly located in plasma membrane, mitochondria and microsomes
Rattus norvegicus
5739
-
3.1.3.4
plasma membrane
the Mg2+-independent enzyme is mainly located in plasma membrane, mitochondria and microsomes
Rattus norvegicus
5886
-
Metals/Ions (protein specific)
EC Number
Metals/Ions
Commentary
Organism
Structure
3.1.3.4
Mg2+
adipose tissue contains 2 different enzyme forms: a Mg2+-dependent form and a Mg2+-independent form
Rattus norvegicus
Natural Substrates/ Products (Substrates) (protein specific)
EC Number
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
3.1.3.4
additional information
Rattus norvegicus
-
?
-
-
-
Source Tissue (protein specific)
EC Number
Source Tissue
Commentary
Organism
Textmining
3.1.3.4
adipose tissue
-
Rattus norvegicus
-
Substrates and Products (Substrate) (protein specific)
EC Number
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
3.1.3.4
additional information
-
134882
Rattus norvegicus
?
-
-
-
-
3.1.3.4
phosphatidic acid + H2O
-
134882
Rattus norvegicus
1,2-diacyl-sn-glycerol + phosphate
-
-
-
?