BRENDA - Enzyme Database

The effects of amphiphilic cationic drugs and inorganic cations on the activity of phosphatidate phosphohydrolase

Bowley, M.; Cooling, J.; Burditt, S.L.; Brindley, D.N.; Biochem. J. 165, 447-454 (1977)

Data extracted from this reference:

Activating Compound
EC Number
Activating Compound
Commentary
Organism
Structure
3.1.3.4
chlorpromazine
stimulates in absence of added Mg2+
Rattus norvegicus
3.1.3.4
spermidine
stimulates
Rattus norvegicus
3.1.3.4
spermine
stimulates
Rattus norvegicus
Inhibitors
EC Number
Inhibitors
Commentary
Organism
Structure
3.1.3.4
Ca2+
inhibition at optimal concentrations of Mg2+
Rattus norvegicus
3.1.3.4
chlorpromazine
competitive inhibition at optimal concentrations of Mg2+
Rattus norvegicus
Metals/Ions
EC Number
Metals/Ions
Commentary
Organism
Structure
3.1.3.4
Ca2+
stimulates
Rattus norvegicus
3.1.3.4
Co2+
stimulates
Rattus norvegicus
3.1.3.4
Fe2+
stimulates
Rattus norvegicus
3.1.3.4
Fe3+
stimulates
Rattus norvegicus
3.1.3.4
Mg2+
required
Rattus norvegicus
3.1.3.4
Mn2+
-
Rattus norvegicus
Organism
EC Number
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
3.1.3.4
Rattus norvegicus
-
-
-
Source Tissue
EC Number
Source Tissue
Commentary
Organism
Textmining
3.1.3.4
liver
-
Rattus norvegicus
-
Substrates and Products (Substrate)
EC Number
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
3.1.3.4
phosphatidic acid + H2O
-
134877
Rattus norvegicus
1,2-diacyl-sn-glycerol + phosphate
-
-
-
?
Activating Compound (protein specific)
EC Number
Activating Compound
Commentary
Organism
Structure
3.1.3.4
chlorpromazine
stimulates in absence of added Mg2+
Rattus norvegicus
3.1.3.4
spermidine
stimulates
Rattus norvegicus
3.1.3.4
spermine
stimulates
Rattus norvegicus
Inhibitors (protein specific)
EC Number
Inhibitors
Commentary
Organism
Structure
3.1.3.4
Ca2+
inhibition at optimal concentrations of Mg2+
Rattus norvegicus
3.1.3.4
chlorpromazine
competitive inhibition at optimal concentrations of Mg2+
Rattus norvegicus
Metals/Ions (protein specific)
EC Number
Metals/Ions
Commentary
Organism
Structure
3.1.3.4
Ca2+
stimulates
Rattus norvegicus
3.1.3.4
Co2+
stimulates
Rattus norvegicus
3.1.3.4
Fe2+
stimulates
Rattus norvegicus
3.1.3.4
Fe3+
stimulates
Rattus norvegicus
3.1.3.4
Mg2+
required
Rattus norvegicus
3.1.3.4
Mn2+
-
Rattus norvegicus
Source Tissue (protein specific)
EC Number
Source Tissue
Commentary
Organism
Textmining
3.1.3.4
liver
-
Rattus norvegicus
-
Substrates and Products (Substrate) (protein specific)
EC Number
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
3.1.3.4
phosphatidic acid + H2O
-
134877
Rattus norvegicus
1,2-diacyl-sn-glycerol + phosphate
-
-
-
?