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Literature summary extracted from

  • Jamdar, S.C.; Osborne, L.J.
    Glycerolipid biosynthesis in rat adipose tissue. 11. Effects of polyamines on Mg2+-dependent phosphatidate phosphohydrolase (1983), Biochim. Biophys. Acta, 752, 79-88.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
3.1.3.4 polyamines activate in presence of Mg2+, no activation in absence of Mg2+ Rattus norvegicus
3.1.3.4 putrescine activate in presence of Mg2+, no activation in absence of Mg2+. Effective at 2-5 mM Rattus norvegicus
3.1.3.4 spermidine activates in presence of Mg2+, no activation in absence of Mg2+. Effective at 1 mM Rattus norvegicus
3.1.3.4 spermine activates in presence of Mg2+, no activation in absence of Mg2+. Effective at 0.5-1 mM, inhibitory at higher concentrations Rattus norvegicus

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.1.3.4 spermine above 1 mM Rattus norvegicus

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
3.1.3.4 0.098
-
 phosphatidic acid in presence of various polyamines Rattus norvegicus
3.1.3.4 0.16
-
 phosphatidic acid without polyamines Rattus norvegicus

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
3.1.3.4 Mg2+ required Rattus norvegicus

Organism

EC Number Organism UniProt Comment Textmining
3.1.3.4 Rattus norvegicus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.1.3.4 adipose tissue
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.1.3.4 phosphatidic acid + H2O
-
 Rattus norvegicus 1,2-diacyl-sn-glycerol + phosphate
-
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