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Literature summary extracted from
- Protein phosphatase type-2C isozymes present in vertebrate retinae: purification, characterization, and localization in photoreceptors (1998), J. Neurosci. Res., 51, 328-338.
Cloned(Commentary)
| EC Number | Cloned (Comment) | Organism |
|---|---|---|
| 3.1.3.16 | PP2Calpha and PP2Cbeta | Bos taurus |
Inhibitors
| EC Number | Inhibitors | Comment | Organism | Structure |
|---|---|---|---|---|
| 3.1.3.16 | Ca2+ | degree of inhibition depends on concentration of Mg2+ | Bos taurus |  |
| 3.1.3.16 | okadaic acid | no inhibition of phosphatase PP2C | Bos taurus | |
Metals/Ions
| EC Number | Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|---|
| 3.1.3.16 | Mg2+ | - |
Bos taurus | |
| 3.1.3.16 | Mn2+ | - |
Bos taurus | |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 3.1.3.16 | Bos taurus | - |
- |
- |
Purification (Commentary)
| EC Number | Purification (Comment) | Organism |
|---|---|---|
| 3.1.3.16 | PP2C | Bos taurus |
Source Tissue
| EC Number | Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|---|
| 3.1.3.16 | photoreceptor | outer segment of rod photoreceptors | Bos taurus | - |
| 3.1.3.16 | retina | outer segment of rod photoreceptors | Bos taurus | - |
Specific Activity [micromol/min/mg]
| EC Number | Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|---|
| 3.1.3.16 | 0.003 | 0.015 | phosphatases PP2Calpha, PP2Cbeta, substrate casein | Bos taurus |
Storage Stability
| EC Number | Storage Stability | Organism |
|---|---|---|
| 3.1.3.16 | 4°C, or -20°C, or -70°C, half-life 24 h, inactivation is not prevented by addition of glycerol, bovine serum albumin, divalent cations or SH-reagents | Bos taurus |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 3.1.3.16 | phosphocasein + H2O | - |
Bos taurus | casein + phosphate | - |
? | |
| 3.1.3.16 | phosphoproteins + H2O | - |
Bos taurus | proteins + phosphate | - |
? | |
Temperature Optimum [°C]
| EC Number | Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|---|
| 3.1.3.16 | 45 | 55 | phosphatase PP2C | Bos taurus |
pH Optimum
| EC Number | pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|---|
| 3.1.3.16 | 7.5 | 8 | phosphatase PP2C | Bos taurus |
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Release 2023.1 (January 2023)
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