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Literature summary extracted from

  • Martin, B.L.; Graves, D.J.
    The chemical mechanism of calcineurin: A model for phosphotyrosyl protein phosphatases (1987), Adv. Protein Phosphatases, 4, 95-125.
No PubMed abstract available

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.1.3.16 pentafluorophenol
-
 Bos taurus

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
3.1.3.16 1.7
-
 Tetrafluorotyrosine phosphate
-
 Bos taurus
3.1.3.16 4.2
-
 fluorotyrosine phosphate
-
 Bos taurus
3.1.3.16 6.2
-
 tyrosine phosphate
-
 Bos taurus
3.1.3.16 10.1
-
 p-nitrophenyl phosphate
-
 Bos taurus

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
3.1.3.16 Mg2+
-
 Bos taurus
3.1.3.16 Mn2+ activation Bos taurus

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
3.1.3.16 80000 90000 phosphatase 2B, i.e. calcineurin, sedimentation equilibrium centrifugation Bos taurus

Organism

EC Number Organism UniProt Comment Textmining
3.1.3.16 Bos taurus
-
-
-

Reaction

EC Number Reaction Comment Organism Reaction ID
3.1.3.16 [a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate mechanism of calcineurin catalysed reaction Bos taurus
a

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.1.3.16 brain
-
 Bos taurus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.1.3.16 fluorotyrosine phosphate + H2O
-
 Bos taurus fluorotyrosine + phosphate
-
 ?
3.1.3.16 p-nitrophenyl phosphate + H2O
-
 Bos taurus p-nitrophenol + phosphate
-
 ?
3.1.3.16 phospho-D,L-tyrosine + H2O
-
 Bos taurus D,L-tyrosine + phosphate
-
 ?
3.1.3.16 phospho-L-tyrosine + H2O
-
 Bos taurus L-tyrosine + phosphate
-
 ?
3.1.3.16 phosphoproteins + H2O comparison of amino acid sequence of substrates at phosphorylated sites Bos taurus proteins + phosphate
-
 ?
3.1.3.16 tetrafluorotyrosine phosphate + H2O
-
 Bos taurus tetrafluorotyrosine + phosphate
-
 ?

Subunits

EC Number Subunits Comment Organism
3.1.3.16 dimer calcineurin B: 19200, Ca2+ binding, 35% homology with bovine brain calmodulin Bos taurus

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
3.1.3.16 7
-
-
 Bos taurus