Any feedback?
Literature summary extracted from
- Regulation of rat liver HMG-CoA reductase by reductase kinase and the cytosolic and microsomal protein phosphatases (1986), Adv. Protein Phosphatases, 3, 1-30.
No PubMed abstract available
Inhibitors
| EC Number | Inhibitors | Comment | Organism | Structure |
|---|---|---|---|---|
| 3.1.3.16 | 3-hydroxy-3-methylglutaryl CoA | - |
Rattus norvegicus |  |
| 3.1.3.16 | ATP | - |
Rattus norvegicus | |
| 3.1.3.16 | citrate | - |
Rattus norvegicus | |
| 3.1.3.16 | F- | - |
Rattus norvegicus | |
| 3.1.3.16 | NADPH | - |
Rattus norvegicus | |
Localization
| EC Number | Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|---|
| 3.1.3.16 | cytoplasm | - |
Rattus norvegicus | 5737 | - |
| 3.1.3.16 | microsome | phosphatase IIm | Rattus norvegicus | - |
- |
Metals/Ions
| EC Number | Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|---|
| 3.1.3.16 | Ca2+ | - |
Rattus norvegicus | |
| 3.1.3.16 | Co2+ | - |
Rattus norvegicus | |
| 3.1.3.16 | Mg2+ | - |
Rattus norvegicus | |
| 3.1.3.16 | Mn2+ | activation | Rattus norvegicus | |
Natural Substrates/ Products (Substrates)
| EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 3.1.3.16 | phosphoprotein + H2O | Rattus norvegicus | control of cholesterol genesis | protein + phosphate | - |
? | |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 3.1.3.16 | Rattus norvegicus | - |
- |
- |
Purification (Commentary)
| EC Number | Purification (Comment) | Organism |
|---|---|---|
| 3.1.3.16 | 2 forms | Rattus norvegicus |
Source Tissue
| EC Number | Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|---|
| 3.1.3.16 | liver | - |
Rattus norvegicus | - |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 3.1.3.16 | phosphophosphorylase kinase + H2O | specific for alpha-subunit | Rattus norvegicus | phosphorylase kinase + phosphate | - |
? | |
| 3.1.3.16 | phosphoprotein + H2O | control of cholesterol genesis | Rattus norvegicus | protein + phosphate | - |
? | |
| 3.1.3.16 | phosphoproteins + H2O | - |
Rattus norvegicus | proteins + phosphate | - |
? | |
| 3.1.3.16 | phosphorylated 3-hydroxy 3-methylglutaryl coenzyme A reductase + H2O | - |
Rattus norvegicus | 3-hydroxy 3-methylglutaryl coenzyme A reductase + phosphate | - |
? | |
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Release 2023.1 (January 2023)
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