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Literature summary extracted from

  • Ballou, L.M.; Fischer, E.H.
    Phosphoprotein phosphatases (1986), The Enzymes, 3rd Ed. (Boyer, P. D. , ed.), 17, 311-361.
No PubMed abstract available

Activating Compound

EC Number Activating Compound Comment Organism Structure
3.1.3.16 histone
-
 Oryctolagus cuniculus

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.1.3.16 Fe2+
-
 Oryctolagus cuniculus
3.1.3.16 N-ethylmaleimide
-
 Oryctolagus cuniculus
3.1.3.16 p-chloromercuribenzoate
-
 Oryctolagus cuniculus
3.1.3.16 phosphate
-
 Oryctolagus cuniculus
3.1.3.16 Zn2+
-
 Oryctolagus cuniculus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
3.1.3.16 cytoplasm
-
 Mammalia 5737
-
3.1.3.16 cytoplasm
-
 Oryctolagus cuniculus 5737
-

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
3.1.3.16 Ca2+ required by B subunit of calcineurin, four binding sites Mammalia
3.1.3.16 Ca2+ required by B subunit of calcineurin, four binding sites Oryctolagus cuniculus
3.1.3.16 Co2+
-
 Mammalia
3.1.3.16 Co2+
-
 Oryctolagus cuniculus
3.1.3.16 Mg2+
-
 Meleagris gallopavo
3.1.3.16 Mg2+
-
 Mammalia
3.1.3.16 Mg2+
-
 Oryctolagus cuniculus
3.1.3.16 Mn2+ activation Meleagris gallopavo
3.1.3.16 Mn2+ activation Mammalia
3.1.3.16 Mn2+ activation Oryctolagus cuniculus
3.1.3.16 Mn2+ depending on source of enzyme and substrate Mammalia
3.1.3.16 Mn2+ depending on source of enzyme and substrate Oryctolagus cuniculus
3.1.3.16 Ni2+ activation Mammalia
3.1.3.16 Ni2+ activation Oryctolagus cuniculus

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
3.1.3.16 80000 90000 phosphatase 2B, i.e. calcineurin, sedimentation equilibrium centrifugation Mammalia
3.1.3.16 80000 90000 phosphatase 2B, i.e. calcineurin, sedimentation equilibrium centrifugation Oryctolagus cuniculus

Organism

EC Number Organism UniProt Comment Textmining
3.1.3.16 Mammalia
-
-
-
3.1.3.16 Meleagris gallopavo
-
-
-
3.1.3.16 Oryctolagus cuniculus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.1.3.16 adipose tissue
-
 Oryctolagus cuniculus
-
3.1.3.16 brain
-
 Oryctolagus cuniculus
-
3.1.3.16 brain mammals, calcineurin, i.e. phosphatase 2 B Mammalia
-
3.1.3.16 additional information
-
 Mammalia
-
3.1.3.16 additional information
-
 Oryctolagus cuniculus
-
3.1.3.16 nerve calcineurin, i.e. phosphatase 2B Mammalia
-
3.1.3.16 smooth muscle
-
 Meleagris gallopavo
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
3.1.3.16 additional information
-
-
 Mammalia
3.1.3.16 additional information
-
-
 Oryctolagus cuniculus

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.1.3.16 phosphohistone + H2O
-
 Meleagris gallopavo histone + phosphate
-
 ?
3.1.3.16 phosphohistone + H2O
-
 Oryctolagus cuniculus histone + phosphate
-
 ?
3.1.3.16 phosphomyosin light chain + H2O
-
 Meleagris gallopavo myosin light chain + phosphate
-
 ?
3.1.3.16 phosphomyosin light chain + H2O
-
 Oryctolagus cuniculus myosin light chain + phosphate
-
 ?
3.1.3.16 phosphophosphorylase kinase + H2O specific for alpha-subunit Oryctolagus cuniculus phosphorylase kinase + phosphate
-
 ?
3.1.3.16 phosphoprotamine + H2O
-
 Oryctolagus cuniculus protamine + phosphate
-
 ?
3.1.3.16 phosphoproteins + H2O
-
 Meleagris gallopavo proteins + phosphate
-
 ?
3.1.3.16 phosphoproteins + H2O
-
 Mammalia proteins + phosphate
-
 ?
3.1.3.16 phosphoproteins + H2O
-
 Oryctolagus cuniculus proteins + phosphate
-
 ?
3.1.3.16 phosphorylase a + H2O
-
 Meleagris gallopavo phosphorylase b + phosphate
-
 ?
3.1.3.16 phosphorylase a + H2O
-
 Oryctolagus cuniculus phosphorylase b + phosphate
-
 ?
3.1.3.16 phosphorylated brain proteins + H2O e.g. DARPP-32, G-substrate, both phosphorylated at threonine, similar amino acid sequences and phosphorylation sites, protein K-F. Oryctolagus cuniculus brain proteins + phosphate
-
 ?
3.1.3.16 phosphorylated inhibitor-1 + H2O
-
 Oryctolagus cuniculus inhibitor-1 + phosphate
-
 ?
3.1.3.16 phosphorylated inhibitor-2 + H2O
-
 Oryctolagus cuniculus inhibitor-2 + phosphate
-
 ?

Subunits

EC Number Subunits Comment Organism
3.1.3.16 dimer
-
 Meleagris gallopavo
3.1.3.16 dimer
-
 Mammalia
3.1.3.16 tetramer AB'C2, phosphatase 2A0, A: 60000, B: 54000, C: 36000, rabbit, SDS-PAGE Oryctolagus cuniculus

Cofactor

EC Number Cofactor Comment Organism Structure
3.1.3.16 Calmodulin activation, dependent on Ca2+ Mammalia
3.1.3.16 Calmodulin activation, dependent on Ca2+ Oryctolagus cuniculus