Literature summary extracted from

Van Dijk, H.; Sloots, B.; van der Berg, A.; Gaastra, W.; Beintema, J.J.
The primary structure of muskrat pancreatic ribonuclease (1976), Int. J. Pept. Protein Res., 8, 305-316.

Natural Substrates/ Products (Substrates)

EC Number	Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
4.6.1.18	RNA + H2O	Ondatra zibethicus	endonucleolytic cleavage to 3'-phosphomononucleotides and 3'-phosphooligonucleotides ending in Cp or Up with 2',3'-cyclic phosphate intermediates, e.g. tRNA, 18S and 28S rRNA, yeast RNA,4.5S RNA	3'-phosphomononucleotides + 3'-phosphooligonucleotides	-	?

Organism

EC Number	Organism	UniProt	Comment	Textmining
4.6.1.18	Ondatra zibethicus	-	muskrat	-

Purification (Commentary)

EC Number	Purification (Comment)	Organism
4.6.1.18	partial	Ondatra zibethicus

Source Tissue

EC Number	Source Tissue	Comment	Organism	Textmining

Substrates and Products (Substrate)

EC Number	Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
4.6.1.18	cyclic 2',3'-nucleoside monophosphate + H2O	second step of hydrolysis is irreversible	Ondatra zibethicus	3'-phosphomononucleotides	-	ir
4.6.1.18	RNA + H2O	endonucleolytic cleavage to 3'-phosphomononucleotides and 3'-phosphooligonucleotides ending in Cp or Up with 2',3'-cyclic phosphate intermediates, e.g. tRNA, 18S and 28S rRNA, yeast RNA,4.5S RNA	Ondatra zibethicus	3'-phosphomononucleotides + 3'-phosphooligonucleotides	-	?
4.6.1.18	RNA + H2O	first step of hydrolysis is reversible	Ondatra zibethicus	cyclic 2',3'-nucleoside monophosphate	-	r

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Release 2023.1 (January 2023)